Cistanches Herba: An overview of its chemistry, pharmacology, and pharmacokinetics property

Fu, Zhifei; Fan, Xiang; Wang, Xiaoying; Gao, Xiumei

doi:10.1016/j.jep.2017.10.015

Cited by 93 publications

(61 citation statements)

References 121 publications

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“…Our study showed that DM intake and the digestibility of DM, OM, and NDF increased following the dietary addition of C. deserticola, and average body weight gain (BWG) and feed conversion ratio (FCR) in the CD 4% and CD 6% groups were greater than that in the control group. This could be explained by that chemical analysis of C. deserticola [20], which indicates that polysaccharides in the C. deserticola are one of the chemical components with properties most likely to influence sheep digestive physiology [21]. The results agree with the views in previous studies that polysaccharides in plants could affect ruminants' feed intake and nutrient digestibility [22].…”

Section: Feed Intake Digestibility and Bwgsupporting

confidence: 88%

Cistanche deserticola Addition Improves Growth, Digestibility, and Metabolism of Sheep Fed on Fresh Forage from Alfalfa/Tall Fescue Pasture

Liu

Yan

et al. 2020

Animals

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This study is targeted at evaluating whether C. deserticola addition promotes digestion, nitrogen and energy use, and methane production of sheep fed on fresh forage from alfalfa/tall fescue pastures. The sheep feeding trial was conducted with four addition levels with C. deserticola powder, and a basal diet of fresh alfalfa (Medicago sativa) and tall fescue (Festuca arundinacea). Addition levels of 4% and 6% improved average body weight gain (BWG) by 215.71 and 142.86 g/d, and feed conversion ratio (FCR) by 0.20 and 0.14, respectively. Digestibility of dry matter (DM), organic matter (OM), neutral detergent fiber (NDF), and ether extract (EE) was 62.25%, 65.18%, 58.75%, and 47.25% under the addition level of 2%, which is greater than that in the control group. C. deserticola addition improved energy utilization efficiency, while addition levels of 2% and 4% increased nitrogen intake and deposited nitrogen. Overall, C. deserticola has the potential to improve growth performance, digestion of sheep, so it has suitability to be used as a feed additive.

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Section: Feed Intake Digestibility and Bwgsupporting

confidence: 88%

Cistanche deserticola Addition Improves Growth, Digestibility, and Metabolism of Sheep Fed on Fresh Forage from Alfalfa/Tall Fescue Pasture

Liu

Yan

et al. 2020

Animals

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“…[11][12][13] Deng et al found that the echinacoside, one of the major active compounds of cistanche, exhibited protective effects on TNF-α-induced SH-SY5Y cell apoptosis. Modern pharmacological studies have demonstrated that cistanches possesses broad medicinal functions, especially on the central nervous system (CNS), including anti-apoptosis, anti-oxidation, anti-ageing, anti-fatigue, immunomodulatory anti-inflammatory and neuroprotection.…”

Section: Introductionmentioning

confidence: 99%

“…Modern pharmacological studies have demonstrated that cistanches possesses broad medicinal functions, especially on the central nervous system (CNS), including anti-apoptosis, anti-oxidation, anti-ageing, anti-fatigue, immunomodulatory anti-inflammatory and neuroprotection. [11][12][13] Deng et al found that the echinacoside, one of the major active compounds of cistanche, exhibited protective effects on TNF-α-induced SH-SY5Y cell apoptosis. 14 Phenylethanoid glycosides, another major active compounds of cistanche, which provided abundant phenolic hydroxyl, can serve as hydrogen donor to reductive radicals and thus scavenge them.…”

Section: Introductionmentioning

confidence: 99%

Cistanches alleviates sevoflurane‐induced cognitive dysfunction by regulating PPAR‐γ‐dependent antioxidant and anti‐inflammatory in rats

Peng

Liu

et al. 2019

J Cellular Molecular Medi

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This study aimed to investigate the protective effects and underlying mechanisms of cistanche on sevoflurane-induced aged cognitive dysfunction rat model. Aged (24 months) male SD rats were randomly assigned to four groups: control group, sevoflurane group, control + cistanche and sevoflurane + cistanche group. Subsequently, inflammatory cytokine levels were measured by ELISA, and the cognitive dysfunction of rats was evaluated by water maze test, open-field test and the fear conditioning test. Three days following anaesthesia, the rats were killed and hippocampus was harvested for the analysis of relative biomolecules. The oxidative stress level was indicated as nitrite and MDA concentration, along with the SOD and CAT activity.Finally, PPAR-γ antagonist was used to explore the mechanism of cistanche in vivo.The results showed that after inhaling the sevoflurane, 24-but not 3-month-old male SD rats developed obvious cognitive impairments in the behaviour test 3 days after anaesthesia. Intraperitoneal injection of cistanche at the dose of 50 mg/kg for 3 consecutive days before anaesthesia alleviated the sevoflurane-induced elevation of neuroinflammation levels and significantly attenuated the hippocampus-dependent memory impairments in 24-month-old rats. Cistanche also reduced the oxidative stress by decreasing nitrite and MDA while increasing the SOD and CAT activity.Moreover, such treatment also inhibited the activation of microglia. In addition, we demonstrated that PPAR-γ inhibition conversely alleviated cistanche-induced protective effect. Taken together, we demonstrated that cistanche can exert antioxidant, anti-inflammatory, anti-apoptosis and anti-activation of microglia effects on the development of sevoflurane-induced cognitive dysfunction by activating PPAR-γ signalling. K E Y W O R D Scistanche, postoperative cognitive dysfunction (POCD), PPAR-γ, sevoflurane

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“…In our study, we observed a signi cantly (P < 0.01) improved frequency of nocturia in the subjects of the product group (data not shown). The bene cial effect of our product on the nocturia mainly contributed to the cistanche, a well-known kidney yang-tonifying herb of TCM [7,19]. Improving memory is the original health claim of our product [8,9].…”

Section: Discussionmentioning

confidence: 99%

A botanical product containing cistanche and ginkgo extracts improves chronic fatigue syndrome: a randomized, double-blind, placebo-controlled study

Kan¹,

Hu²,

Chen³

et al. 2020

Preprint

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BackgroundDietary therapy may be beneficial in alleviating symptoms of chronic fatigue syndrome (CFS), a disorder characterized by extreme fatigue with no underlying medical condition. The aim of this study is to evaluate the protective effect of a botanical product containing cistanche (Cistanche tubulosa (Schenk) Wight) and ginkgo (Ginkgo biloba L.) extracts on adults with CFS in a randomized, double-blind, placebo-controlled clinical trial.MethodsA total of 190 subjects with CFS were randomized to receive low dose, high dose of product or placebo (tablets) once daily for 60 days. Blood samples and questionnaires of Chalder fatigue, quality of life (QOL), and sexual life quality (SLQ) were collected at baseline and post-intervention.ResultsOur product significantly relieved the symptoms of CFS, among which impaired memory or concentration, muscle pain, unrefreshing sleep, and post-exertional malaise were significantly improved. The intervention of product significantly decreased both physical and mental fatigue scores of the Chalder fatigue questionnaire, and improved QOL and SLQ of the subjects. Levels of blood ammonia and lactic acid in the subjects of product group were significantly lower than those of placebo group. In addition, the change in lactic acid concentration was significantly associated with the effectiveness for CFS symptoms, and correlated to the change in total physical fatigue score of the Chalder fatigue questionnaire.ConclusionsOur botanical product relieves the CFS symptoms and improves the scores of Chalder fatigue, QOL and SLQ questionnaires. These findings suggest a nutritional supplementation approach with botanical extracts as an alternative strategy in mitigating CFS.Trial registrationThis trial has been registered on https://clinicaltrials.gov/ under the identification code: NCT02807649. Registered 21 June 2016 - Retrospectively registered.

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Cistanches Herba: An overview of its chemistry, pharmacology, and pharmacokinetics property

Cited by 93 publications

References 121 publications

Cistanche deserticola Addition Improves Growth, Digestibility, and Metabolism of Sheep Fed on Fresh Forage from Alfalfa/Tall Fescue Pasture

Cistanche deserticola Addition Improves Growth, Digestibility, and Metabolism of Sheep Fed on Fresh Forage from Alfalfa/Tall Fescue Pasture

Cistanches alleviates sevoflurane‐induced cognitive dysfunction by regulating PPAR‐γ‐dependent antioxidant and anti‐inflammatory in rats

A botanical product containing cistanche and ginkgo extracts improves chronic fatigue syndrome: a randomized, double-blind, placebo-controlled study

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