Cistatina C sérica em cães criticamente enfermos em UTI

Souza, Eliana Matias de; Arndt, Marcio H. L.; Gomes, M.G.; Val, Adriane P. Costa; Leme, Fabíola Oliveira Paes

doi:10.1590/1678-5150-pvb-5695

Cited by 3 publications

(8 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CysC is efficient and early in the diagnosis of AKI compared to creatinine (Segev et al, 2016, Souza et al, 2018. The present study diagnosed kidney damage in nine (32.14%) animals in the first 24 hours after admission to the ICU, with eight (89%) showing ultrasound changes.…”

Section: Discussionmentioning

confidence: 60%

“…Early diagnosis of AKI favors implementing strategies to reduce the morbidity and mortality of affected patients; however, it still represents a challenge in veterinary medicine (Coca et al, 2008). Serum cystatin C (CysC) stands out for having the best correlation with the Glomerular Filtration Rate (GFR) (Miyagawa et al, 2021), being less influenced by extra-renal factors and for being earlier in comparison to serum creatinine, being considered an excellent early marker of AKI (Souza et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…CysC was measured 24, 48 and 72 hours after admission to the Veterinary Hospital using an immunoturbidimetric method (Cystatin C Turbiquest Plus-Labtest®) previously calibrated with purified canine CysC (BioVendor Research and Diagnostic products). The reference range used was 0.57mg/L to 1.2mg/L according to (Souza et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Correlation between renal ultrasonography and serum cystatin C in acute kidney disease of critically ill dogs

Souza

Muniz

Costa-Val

et al. 2022

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

Acute kidney injury (AKI) is defined as the rapid decline in kidney function. Its development is related to critical clinical statuses, such as sepsis, complicated post-surgical recovery, and infectious diseases. Serum cystatin C (CysC) has the best correlation with the glomerular filtration rate. Ultrasonography stands out because it is highly accessible and can be done at the bedside. Twenty-eight dogs admitted to the intensive care unit with serum creatinine values <1.6 mg/dL and at-risk factors of AKI development were selected. CysC measurements and ultrasound assessments were performed daily for 72 hours. Using CysC dosage, 22/28 animals (78.6%) were considered to have AKI, and 17/22 had ultrasound compatible with AKI changes, demonstrating moderate agreement with CysC dosage. Increased cortical renal echogenicity is the most prevalent alteration in critically ill patients and is correlated with serum increases in CysC and is associated with renal structural damage.

show abstract

Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Correlation between renal ultrasonography and serum cystatin C in acute kidney disease of critically ill dogs

Souza

Muniz

Costa-Val

et al. 2022

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

show abstract

“… * IRIS AKI based on historical, serum creatinine >1.6 mg/dl or increase of 0.3 mg/dl of serum creatinine within 48 h and/or a reduction in urinary output (<1 ml/kg/h) ou anuria over 6 h, ** ( 26 ) . …”

Section: Resultsmentioning

confidence: 99%

Cystatin C and Iris: Advances in the Evaluation of Kidney Function in Critically Ill Dog

et al. 2021

Self Cite

View full text Add to dashboard Cite

Critically ill hospitalized dogs are subject to certain complications, being acute kidney injury (AKI) a common one. Early diagnosis is crucial, and Cystatin C (CysC) is a reliable and early biomarker. The International Society of Renal Interest (IRIS) states that AKI severity can be assessed by mild changes in creatinine serum levels or reduction of urine output that cannot be considered biomarkers of renal injury but failure or insufficiency. Twenty-eight dogs admitted to the Intensive Care Unit under risk factors for the development of AKI were evaluated. Blood samples were collected for determination of sCr and CysC at admission and after 24, 48, and 72 h. Urine output was measured by daily monitoring, measured by collection in a closed system. The results showed the incidence of AKI was 67.9% based on the IRIS criteria and 78.6% based on cystatin C in critically ill patients' dogs. The measurement of serum cystatin C immediately on admission to the ICU was superior in the early identification of patients with AKI when compared to the IRIS classification and serum creatinine in critically ill dogs.

show abstract

“…A cistatina C é livremente filtrada pelos glomérulos, sendo quase totalmente removida da circulação. Sua metabolização se dá nos túbulos proximais distais, onde ocorre reabsorção quase completa (99%) pelas células tubulares, e posterior degradação enzimática dentro dos lisossomos (Souza et al, 2018).…”

Section: Taxa De Filtração Glomerularunclassified

Injúria renal aguda em felinos: etiologia, diagnóstico e prevenção

Cipriano,

Tinoco,

Eliam

et al. 2024

RSD

View full text Add to dashboard Cite

Na clínica veterinária de pequenos animais, a Injúria Renal Aguda (IRA) em felinos é uma enfermidade de ocorrência comum. A doença renal afeta um a cada três gatos, com mais de doze anos de idade, sendo uma das maiores causas de óbito nessa espécie. A IRA é uma síndrome clínica causada por danos renais, sendo caracterizada por um aumento nas concentrações séricas de ureia e creatinina, levando ao animal a apresentar uma série de sinais clínicos, tais como inapetência, vômito e estomatite, podendo levar inclusive ao óbito. Dessa maneira, é importante que o veterinário identifique e aplique o protocolo que melhor se ajuste a um paciente com IRA. No caso dos felinos, a IRA torna-se ainda mais preocupante, por causa das particularidades anatômicas da espécie. Nesse sentido, objetiva-se com este trabalho fazer uma revisão de literatura sobre as causas que levam a esse distúrbio, apontar os sinais clínicos dessa enfermidade e destacar algumas diretrizes de prevenção para a IRA em gatos.

show abstract

Cistatina C sérica em cães criticamente enfermos em UTI

Cited by 3 publications

References 63 publications

Correlation between renal ultrasonography and serum cystatin C in acute kidney disease of critically ill dogs

Correlation between renal ultrasonography and serum cystatin C in acute kidney disease of critically ill dogs

Cystatin C and Iris: Advances in the Evaluation of Kidney Function in Critically Ill Dog

Injúria renal aguda em felinos: etiologia, diagnóstico e prevenção

Contact Info

Product

Resources

About