Purpose: To objectively identify the 50 most influential studies in knee arthroscopy and provide an analysis of their key characteristics. Methods: The Clarivate Analytics Web of Knowledge database was used to gather data and metrics of knee arthroscopy research. The search list was sorted by the number of citations, and articles were included or excluded based on relevance to knee arthroscopy. The information extracted for each article included author name, publication year, country of origin, journal name, article type, and the level of evidence. Results: For these 50 studies, the total number of citations was calculated to be 12,168, with an average of 243.4 citations per paper. The most-cited article was cited 1,220 times. The 50 studies included in this analysis were published between 1972 and 2013. All 50 articles were published in English and came from 10 different orthopaedic journals. The United States was responsible for the majority of articles (n ¼ 26); however, many other countries were represented. The most prevalent study designs were case series (n ¼ 20). Conclusions: The 50 most influential articles in knee arthroscopy were cited a total of 12,168 times. The study designs most commonly used were case series and cohort studies. This article serves as a reference to direct orthopaedic practitioners to the 50 most influential studies in knee arthroscopy. We hope that these 50 studies and the analysis we provide help health care professionals efficiently assess consensus, trends, and needs within the field. Clinical Relevance: This analysis of the 50 most influential studies in knee arthroscopy will provide medical students, residents, fellows, and attending physicians with a comprehensive inventory and citation analysis of the most impactful academic contributions to one of the most important fields within orthopaedic surgery.A rthroscopic surgery has undoubtedly broadened the field of orthopaedic surgery and significantly improved patient outcomes. 1,2 Arthroscopic procedures are minimally invasive alternatives to open surgery, and, as such, have been associated with decreased recovery times and infection rates. 3,4 In addition, arthroscopy can be performed on almost any joint, with the knee being the most common. 2 In 1912, Severin Nordentoft, became the first physician to visualize the internal structures of a knee joint via endoscope. 5 By 1920, both Kenju Takagi, and Eugen