Citidine-5-diphosphocholine Ameliorates the Impairment of Spatial Memory Induced by Scopolamine

Abstract

The memory enhancing effects of orally administered citidine-5-diphosphocholine or citicoline (CDPcholine) on memory impairment without neuronal cell death are still unknown. We investigated the effects of CDP-choline on memory disturbance induced by scopolamine using an eight-armed radial maze task. Orally repeated administration of CDP-choline or histidine significantly restored the errors impaired by scopolamine. CDP-choline may increase hippocampal and neocortical acetylcholine levels. These results suggest that CDP-choline has ameliorative effects on the impairment of spatial memory induced not only by neuronal cell death but also by impaired cholinergic signal.

Citicoline in the Treatment of Cognitive Impairment

“…Citicoline attenuates vascular cognitive impairment in animal models of brain ischemia [131]. Citicoline also prevents amnesia induced by scopolamine [132][133][134]. Citicoline acts as a drug able to enhance memory in animals with memory deficits from different causes [135][136][137][138][139][140].…”

Citicolina: revisión farmacológica y clínica, actualización 2022

“…Authors suggested that this effect is mediated by drug actions on neurotransmission. Takasaki et al [ 370 ] suggest that citicoline has ameliorative effect on the impairment of spatial memory induced by scopolamine, reducing the neuronal death and improving the impaired cholinergic signal. Citicoline acts as a memory-enhancing drug, and this effect is particularly marked in animals with memory deficits [ 371 ].…”

“…Posteriormente, Mosharrof y Petkov [ 369 ] demostraron que la citicolina en dosis de 100 mg/kg prevenía completamente la amnesia inducida por la escopolamina, así como la asociación de 50 mg/kg de citicolina con 500 mg/kg de piracetam, produciendo, además, un incremento significativo de la retención, y los autores sugieren que este efecto viene mediado por las acciones del fármaco sobre la neurotransmisión. Takasaki et al [ 370 ] sugieren que la citicolina tiene un efecto mejorando el deterioro de la memoria especial inducido por la escopolamina, reduciendo la muerte neuronal y mejorando la señal colinérgica deteriorada. La citicolina actúa como un fármaco potenciador de la memoria y este efecto es particularmente pronunciado en animales con déficits de memoria [ 371 ].…”