Citizen-science based study of the oral microbiome in Cystic fibrosis and matched controls reveals major differences in diversity and abundance of bacterial and fungal species

Abstract

Gabaldón (2021) Citizen-science based study of the oral microbiome in Cystic fibrosis and matched controls reveals major differences in diversity and abundance of bacterial and fungal species,

Citizen-science reveals changes in the oral microbiome in Spain through age and lifestyle factors

“…Some of these variables displayed particular significant differences when compared to their matched controls (Table 2 ). CF 14 and DS 13 have been explored in detail elsewhere, and so are not included in this table. Celiac samples had higher abundances of the genera Phocaeicola and Staphylococcus , and also had lower Faith’s PD values and species richness (the number of species detected in a sample).…”

“…In recent years, however, the relationships of the oral microbiome with systemic diseases or chronic disorders have received growing attention. These include, among others, different cancer types 5 , 6 , cardiovascular diseases 7 , 8 , diabetes 9 , celiac disease 10 – 12 , Down Syndrome (DS) 13 , or cystic fibrosis (CF) 14 . Thanks to these studies, we are beginning to understand how oral or systemic disorders relate to changes in the composition of the oral microbiome.…”

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“…It is also the main reservoir of potentially pathogenic bacteria, including S. aureus , P. aeruginosa , and some Enterobacteriaceae [ 10 , 11 ]. In the most recent publication on this subject, bacterial genera such as Chryseobacterium , Microbacterium , Brevundimonas , Stenotrophomonas , Streptococcus, Rothia , Staphylococcus , Delftia , Comamonas , Scardovia , Mobiluncus Sphingobacterium , Mogibacterium , and the fungal species Candida albicans were identified at higher abundance and prevalence in the oral rinse samples of CF patients [ 12 ]. Conversely, smaller amounts of the genera Treponema , Peptostreptococcus , Alloprevotella , Aggregatibacter , Parvimonas , Bergeyella , Fusobacterium , genera of the order Saccharimonadales , and Clostridiales family were found [ 10 , 11 , 12 ].…”

“…Additionally, the increased energy demand in patients with CF necessitates therapy and nutritional support treatment that promotes the development of caries and increases the severity thereof. However, some studies suggest that, despite creating a low PH and low alpha diversity environment favoring damage to the outer layers of the teeth, the combination of CF common factors can also inhibit cariogenic and periodontal pathogens [ 12 ].…”

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“…In a study aiming to decipher the peri-implantitis and periodontitis key microbial players, the Solobacterium moorei and Prevotella denticola have been presented as an interesting network [ 35 ]. Metabarcoding studies have been only recently applied to find the association among periodontal disease and cystic fibrosis (CF) using matched control samples [ 36 ]. These matched control networks including the oral microbiome as represented by Streptococcus , the Fusobacterium species, Campylobacter spp., Treponema and the Prevotella species to name a few, have exhibited meaningful connections with the pathogenesis of CF [ 36 ].…”