Over the last decades, intersex studies has achieved increasing development as a field of critical knowledge, in tight collaboration with discourses developed by intersex activism and human rights bodies. This paper proposes a self-reflexive review of epistemological perspectives in intersex studies within broader discursive fields, through a thematic analysis and comparative framing analysis. This analysis is based on a narrative literature review of academic contributions, activist declarations, and documents issued by human rights bodies conducted over the last decade as a work-in-progress project. Furthermore, it includes results of a scoping review of recent knowledge production in intersex studies carried out in Scopus within the subject area ‘social sciences’. This paper focuses on the analysis of the following epistemological perspectives: human rights frameworks, legal perspectives and citizenship theories, reflections on biopolitics, medicalization and iatrogenesis, sociology of diagnosis framework, depathologization perspective, respectful health care models, and reflections on epistemological, methodological, and ethical aspects. The literature review raises questions about the existence of specific intersex epistemologies in intersex studies, their interrelation with discourses contributed by intersex activism and human rights bodies, and the opportunities for a contribution of theory making in intersex studies to the human rights protection of intersex people.