Citomegalovirus asociado a úlcera gástrica: caso clínico y revisión de la literatura

Huguet, C; Lázaro, Yolanda Arguedas; Sánchez, Elena del Valle; Sanvicente, Teresa Omiste; Monterde, Vanesa Bernal; Montoro, Miguel

doi:10.1016/j.gastrohep.2018.05.014

Cited by 2 publications

(1 citation statement)

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“…In addition, intraepithelial lymphocytosis in patients with CVID has previously been associated with an altered type I interferon response, which may explain an altered response to the CMV in this case [ 26 ]. CMV has previously been implicated in causing gastric ulcers [ 45 , 46 ]. Recently, it has been postulated as a possible oncogenic herpesvirus and a risk factor for the development of gastric cancer [ 47 , 48 , 49 ], although it is still a controversial issue for some authors [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Possible Role of Cytomegalovirus in Gastric Cancer Development and Recurrent Macrolide-Resistant Campylobacter jejuni Infection in Common Variable Immunodeficiency: A Case Report and Literature Discussion

Díaz-Alberola,

Espuch-Oliver,

Fernández-Segovia

et al. 2024

Microorganisms

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Common variable immunodeficiency (CVID) is the most common symptomatic immunodeficiency in adults. It comprises a group of syndromes whose etiology involves genetic, epigenetic, microbiota, and environmental factors. We present the case of a 46-year-old Caucasian male patient with CVID and an immune dysregulation phenotype. The particular elements of the case consisted of an atypical clinical course, which undoubtedly demonstrates the great variability of clinical manifestations that these types of patients can suffer from, including bacterial and viral infections, autoimmune phenomena, and neoplasia. Notably, the patient suffered from recurrent gastrointestinal infection with macrolide-resistant Campylobacter jejuni and gastroduodenal disease and viraemia by cytomegalovirus (CMV). In addition, CMV was postulated as the main pro-oncogenic factor contributing to the development of early-onset intestinal-type gastric adenocarcinoma, for which the patient underwent gastrectomy. The patient’s evolution was difficult, but finally, as a result of the multidisciplinary approach, clinical stabilization and improvement in his quality of life were achieved. Based on our brief literature review, this is the first reported case of this clinical complexity. Our experience could help with the management of future patients with CVID and may also update current epidemiological data on CVID.

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