Citrate coated iron oxide nanoparticles with enhanced relaxivity for in vivo magnetic resonance imaging of liver fibrosis

Saraswathy, Ariya; Nazeer, Shaiju S.; Jeevan, Madhumol; Nimi, Nirmala; Sabareeswaran, A; Harikrishnan, V. S.; Varma, P. R. Harikrishna; Jayasree, Ramapurath S.

doi:10.1016/j.colsurfb.2014.02.034

Cited by 102 publications

(69 citation statements)

References 43 publications

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“…Monodispersed particles with high magnetic saturation are required for many biological applications, so it is often of interest to functionalize the nanoparticles with a coating layer to prevent agglomeration [5]. The coating layer can also be designed to increase the circulation time and the biocompatibility of the nanoparticles for use as MRI contrast agents and magnetically mediated hyperthermia [6, 7]. Dextran is a biocompatible long chain hydrophilic polymer composed of glucose with mostly α-1, 6 glycoside linkages [8] that strongly physisorb to magnetite nanoparticles in alkaline solutions via non-covalent interactions of the abundant hydroxyl groups resulting in enmeshed nanoparticle cores [3].…”

Section: Introductionmentioning

confidence: 99%

The effects of synthesis method on the physical and chemical properties of dextran coated iron oxide nanoparticles

Hauser

Mathias

Anderson

et al. 2015

Materials Chemistry and Physics

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Iron oxide nanoparticles coated with dextran were synthesized via four variations on the co-precipitation method. The methods ranged from in situ formation of the nanoparticles within the dextran solution to the adsorption of dextran to the nanoparticle surface following nucleation and extensive washing. The timing of the addition of dextran into the reaction mixture was found to greatly influence the physical and chemical properties of the magnetic nanoparticles. Batches of dextran coated iron oxide nanoparticles were synthesized by each method in triplicate, and the nanoparticles were further crosslinked with epichlorohydrin. The properties of the nanoparticles such as size, percentage of dextran coating, stability in solution, crystallinity, and magnetic properties were evaluated. The simultaneous semi-two-step method injected the reducing agent and the dextran solution into the reaction vessel at the same time. This method resulted in the greatest batch-to-batch reproducibility of nanoparticle properties and the least variation in nanoparticles synthesized in the same batch. The two-step method resulted in the greatest variation of the characteristics examined between batches. The one-step method was synthesized with both five grams and one gram of dextran to investigate the effects of solution viscosity on the resulting nanoparticle characteristics. The one-step method with five grams of dextran resulted in nanoparticles with significantly smaller crystal sizes (5.4 ± 1.9 nm) and lower specific adsorption rate (SAR) values (138.4 ± 13.6 W/g) in an alternating magnetic field (58 kA/m, 292 kHz). However, this method resulted in nanoparticles that were very stable in PBS over 12 hours, which is most likely due to the greater dextran coating (60.0 ± 2.7 weight percent). For comparison, the simultaneous semi-two-step method generated nanoparticles 179.2 ± 18.3 nm in diameter (crystal size 12.1 ± 0.2 nm) containing 18.3 ± 1.2 weight percent dextran with a SAR value of 321.1 ± 137.3 W/g.

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Section: Introductionmentioning

confidence: 99%

The effects of synthesis method on the physical and chemical properties of dextran coated iron oxide nanoparticles

Hauser

Mathias

Anderson

et al. 2015

Materials Chemistry and Physics

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“…27–28 A major advantage to capping SPIONs with catechol-functionalized polymers is the improved magnetic properties, 29 which increases T2 contrast enhancement in MR imaging. SPIONs have a large proportion of under-coordinated atoms on the particle surface due to the large surface-area-to-volume ratio inherent to particles at this size.…”

Section: Resultsmentioning

confidence: 99%

Approach to Rapid Synthesis and Functionalization of Iron Oxide Nanoparticles for High Gene Transfection

Stephen

Dayringer

Lim

et al. 2016

ACS Appl. Mater. Interfaces

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Surface functionalization of theranostic nanoparticles (NPs) typically relies on lengthy, aqueous post-synthesis labeling chemistries that have limited ability to fine tune surface properties and can lead to NP heterogeneity. The need for a rapid, simple synthesis approach that can provide great control over the display of functional moieties on NP surfaces has led to increased use of highly selective bioorthoganol chemistries including metal-affinity coordination. Here we report a simple approach for rapid production of a superparamagnetic iron oxide NPs (SPIONs) with tunable functionality and high reproducibility under aqueous conditions. We utilize the high affinity complex formed between catechol and Fe(III) as a means to dock well-defined catechol modified polymer modules on the surface of SPIONs during sonochemical co-precipitation synthesis. Polymer modules consisted of chitosan and poly(ethylene glycol) (PEG) copolymer (CP) modified with catechol (CCP), and CCP functionalized with cationic polyethylenimine (CCP-PEI) to facilitate binding and delivery of DNA for gene therapy. This rapid synthesis/functionalization approach provided excellent control over the extent of PEI labeling, improved SPION magnetic resonance imaging (MRI) contrast enhancement and produced an efficient transfection agent.

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“…The relaxivity ratio (r 2 /r 1 ) increases with increasing particle size [49,50]. Therefore, Resovist (60 nm) [48], dextranstabilized SPIONs (50 nm) [51], and citrate-coated iron oxide nanoparticles (30 nm) [52] have a higher r 2 /r 1 ratio, compared with dextrin-coated IFNPs. Magnetization measurements have showed a decrease in saturation magnetization of iron oxide NPs with decrease in size of particles [53].…”

Section: Phantom Studiesmentioning

confidence: 97%

Synthesis, characterization, in vitro and in vivo studies of dextrin-coated zinc-iron ferrite nanoparticles (Zn0.5Fe0.5Fe2O4) as contrast agent in MRI

et al. 2015

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Iron oxide nanoparticles, such as ferrites, offer some attractive possibilities in biomedicine, especially in MRI applications. The objective of this study is to investigate the effectiveness of dextrin-coated zinc-iron ferrite nanoparticles (IFNPs) as an MRI contrast agent in in vivo and in vitro media. IFNPs were synthesized by an aqueous precipitation method in the presence of dextrin. An agarose phantom with different concentrations of dextrin-coated IFNPs was performed on a 1.5-T MRI. For in vivo MRI studies, implanted melanoma tumors in mice were immediately scanned after intra-tumoral injection of dextrincoated IFNPs. Microscopic studies showed that the average diameter of dextrin-coated IFNPs was 12 ± 2.4 nm and the saturation magnetization for IFNPs was 31.5 emu g -1 ; r 1 and r 2 relaxivities of these ultrasmall superparamagnetic IFNPs in agarose phantom were obtained as 0.99 and 17.4 mmol L -1 s -1 , respectively. The relaxivity measurements revealed that the dextrin-coated IFNPs can serve as a negative contrast agent. In vivo MRI showed that the dextrin-coated IFNPs can be used for tumor detection. The dextrin-coated IFNPs were suggested to be applied for lymph node and targeted imaging.

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Citrate coated iron oxide nanoparticles with enhanced relaxivity for in vivo magnetic resonance imaging of liver fibrosis

Cited by 102 publications

References 43 publications

The effects of synthesis method on the physical and chemical properties of dextran coated iron oxide nanoparticles

The effects of synthesis method on the physical and chemical properties of dextran coated iron oxide nanoparticles

Approach to Rapid Synthesis and Functionalization of Iron Oxide Nanoparticles for High Gene Transfection

Synthesis, characterization, in vitro and in vivo studies of dextrin-coated zinc-iron ferrite nanoparticles (Zn0.5Fe0.5Fe2O4) as contrast agent in MRI

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