Citrate in the diagnosis of prostate cancer

Costello, Leslie C.; Franklin, Renty B.; Narayan, Perinchery

doi:10.1002/(sici)1097-0045(19990215)38:3<237::aid-pros8>3.0.co;2-o

Cited by 152 publications

(92 citation statements)

References 30 publications

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“…Citrate is thus an important in vivo marker of a malignant process. [8][9][10][11] Citrate concentrations in brain tissue (approximately 0.4 mmol/kg 12,13 ) and CSF (approximately 0.2 mmol/L 14 ) are very low, and, to the best of our knowledge, citrate has not been identified with in vivo MR spectroscopy in human brain tissue. …”

Section: Discussionmentioning

confidence: 88%

Citrate in Pediatric CNS Tumors?

Seymour

Panigrahy²,

Finlay³

et al. 2008

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 88%

Citrate in Pediatric CNS Tumors?

Seymour

Panigrahy²,

Finlay³

et al. 2008

AJNR Am J Neuroradiol

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“…Tumor field effects are a result of genetic and molecular alterations in the histologically normal tissues adjacent to tumor, which are either induced by or precursory to tumor 18, 19. If citrate and spermine concentration reductions are genuine prostate tumor field effects (precursory citrate depletion is hypothesized by Costello et al14) then, using MRS, small prostate tumors may be detected early and before morphological imaging techniques are capable of visualizing them.…”

Section: Discussionmentioning

confidence: 99%

TE = 32 ms vs TE = 100 ms echo‐time ¹H‐magnetic resonance spectroscopy in prostate cancer: Tumor metabolite depiction and absolute concentrations in tumors and adjacent tissues

Basharat

Payne

Morgan

et al. 2015

Magnetic Resonance Imaging

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PurposeTo compare the depiction of metabolite signals in short and long echo time (TE) prostate cancer spectra at 3T, and to quantify their concentrations in tumors of different stage and grade, and tissues adjacent to tumor.Materials and MethodsFirst, single‐voxel magnetic resonance imaging (MRI) spectra were acquired from voxels consisting entirely of tumor, as defined on T 2‐weighted and diffusion‐weighted (DW)‐MRI and from a biopsy‐positive octant, at TEs of 32 msec and 100 msec in 26 prostate cancer patients. Then, in a separate cohort of 26 patients, single‐voxel TE = 32 msec MR spectroscopy (MRS) was performed over a partial‐tumor region and a matching, contralateral normal‐appearing region, defined similarly. Metabolite depiction was compared between TEs using Cramér‐Rao lower bounds (CRLB), and absolute metabolite concentrations were calculated from TE = 32 msec spectra referenced to unsuppressed water spectra.ResultsCitrate and spermine resonances in tumor were better depicted (had significantly lower CRLB) at TE = 32 msec, while the choline resonance was better depicted at TE = 100 msec. Citrate and spermine concentrations were significantly lower in patients of more advanced stage, significantly lower in Gleason grade 3+4 than 3+3 tumors, and significantly lower than expected from the tumor fraction in partial‐tumor voxels (by 14 mM and 4 mM, respectively, P < 0.05).ConclusionCitrate and spermine resonances are better depicted at short TE than long TE in tumors. Reduction in these concentrations is related to increasing tumor stage and grade in vivo, while reductions in the normal‐appearing tissues immediately adjacent to tumor likely reflect tumor field effects. J. Magn. Reson. Imaging 2015;42:1086–1093.

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“…This change is due to a metabolic shift of neoplastic cells that become citrate oxidizing with respect to normal prostatic cells that possess a low citrate-oxidizing capability (Costello et al, 1999).…”

Section: Citrate As Secretory End Productmentioning

confidence: 99%

“…For many years, citrate was therefore associated with an essentially bioenergetic role in cell metabolism. Moreover, in normal prostate cells, citrate is a secretory end product of metabolism rather than a substrate of intermediary metabolism (Westergaard et al, 1994;Costello et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Citrate – new functions for an old metabolite

Iacobazzi

Infantino

2014

Biological Chemistry

228

187

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Abstract:Citrate is an important substrate in cellular energy metabolism. It is produced in the mitochondria and used in the Krebs cycle or released into cytoplasm through a specific mitochondrial carrier, CIC. In the cytosol, citrate and its derivatives, acetyl-CoA and oxaloacetate, are used in normal and pathological processes. Beyond the classical role as metabolic regulator, recent studies have highlighted that citrate is involved in inflammation, cancer, insulin secretion, histone acetylation, neurological disorders, and non-alcoholic fatty liver disease. Monitoring changes in the citrate levels could therefore potentially be used as diagnostic tool. This review highlights these new aspects of citrate functions.

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Citrate in the diagnosis of prostate cancer

Cited by 152 publications

References 30 publications

Citrate in Pediatric CNS Tumors?

Citrate in Pediatric CNS Tumors?

TE = 32 ms vs TE = 100 ms echo‐time ¹H‐magnetic resonance spectroscopy in prostate cancer: Tumor metabolite depiction and absolute concentrations in tumors and adjacent tissues

Citrate – new functions for an old metabolite

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Citrate in the diagnosis of prostate cancer

Cited by 152 publications

References 30 publications

Citrate in Pediatric CNS Tumors?

Citrate in Pediatric CNS Tumors?

TE = 32 ms vs TE = 100 ms echo‐time 1H‐magnetic resonance spectroscopy in prostate cancer: Tumor metabolite depiction and absolute concentrations in tumors and adjacent tissues

Citrate – new functions for an old metabolite

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TE = 32 ms vs TE = 100 ms echo‐time ¹H‐magnetic resonance spectroscopy in prostate cancer: Tumor metabolite depiction and absolute concentrations in tumors and adjacent tissues