2015
DOI: 10.1159/000371569
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Citrate versus Acetate-Based Dialysate in On-Line Haemodiafiltration. A Prospective Cross-Over Study

Abstract: Background and Aims: A bicarbonate dialysate acidified with citrate (CD) has been reported to have local anticoagulant effect and improves biocompatibility. This study examines the effect of CD on dialysis efficiency, coagulation, acid-base status, electrolytes, and inflammation in patients in on-line hemodiafiltration (OL-HDF). Methods: 35 patients in OL-HDF were enrolled in a prospective, cross-over study for a 24-week period and two phases alternating CD and acetate dialysate fluid (AD). Parameters on study… Show more

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Cited by 35 publications
(15 citation statements)
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“…Greater buffer delivery and better correction of acidosis would be expected, but this has not been a consistent finding. [81][82][83][84][85]…”
Section: The Anion In the Acid Concentratementioning
confidence: 99%
“…Greater buffer delivery and better correction of acidosis would be expected, but this has not been a consistent finding. [81][82][83][84][85]…”
Section: The Anion In the Acid Concentratementioning
confidence: 99%
“…The impact of citrate dialysate containing the same concentration of calcium on the predialysis PTH serum concentration raises questions; it remained stable in some studies [ 18 , 21 ] or increased in others [ 20 ]. If calcium concentration in citrate dialysate has been increased by 0.15 mEq then postdialysis serum calcium lowers [ 5 , 19 ] and if it has been increased by 0.25 mEq, serum calcium remains stable during dialysis session [ 8 ]. PTH has never been studied if calcium concentration is increased in citrate dialysate.…”
Section: Discussionmentioning
confidence: 99%
“…Consequently, citrate dialysate, known for its improved biocompatibility, has been developed for few years. Compared to acetate, citrate was described to improve depuration of small and large molecules [ 5 7 ], to induce less inflammation [ 5 , 8 – 10 ], to be more physiological on acid-base balance [ 5 , 11 ], and to improve nutritional status [ 12 ]. It results in a better clinical tolerance of the dialysis sessions [ 11 ].…”
Section: Introductionmentioning
confidence: 99%
“…Умеренный антикоагулянтный эффект цитрата был обнаружен еще в одном исследовании [18]; кроме того, авторы отмечали снижение предиализных показателей Среактивного белка и β 2 -микроглобулина, отсутствие последиализной гипокальциемии и умеренные концентрации цитратного иона (0,29 ммоль/л при безопасной для регионарной цитратной антикоагуляции концентрации = 0,89 ммоль/л). Снижение концентраций С-реактивного белка и β 2 -микроглобулина было отмечено и при использовании цитратной ДЖ для гемодиафильтрации [19]. Kuragano et al в течение 4 месяцев после перевода 29 пациентов на лечение диализом с цитратной ДЖ отмечали нормализацию предиализного уровня бикарбоната у больных с исходно низким его уровнем, снижение потребности в эритропоэзстимулирующих препаратах и повышение концентрации альбумина.…”
Section: цитратный ионunclassified