Citric acid cross-linked glucuronoxylans: A pH-sensitive polysaccharide material for responsive swelling-deswelling vs various biomimetic stimuli and zero-order drug release

Hussain, Muhammad Ajaz; Rana, Anam Irshad; Haseeb, Muhammad Tahir; Muhammad, Gulzar; Kiran, L J

doi:10.1016/j.jddst.2019.101470

Cited by 18 publications

(14 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fitting of this kinetic model to swelling of HES‐citrate suggested that this material might provide sustained drug release to target the distal part of gastro‐intestinal tract. [ 19 ]…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization, and Stimuli Responsive On/Off Switching of Cross‐Linked Hydroxyethyl Starch: A Smart Material for Intelligent Drug Delivery

et al. 2022

View full text Add to dashboard Cite

This study reports cross-linking of hydroxyethyl starch (HES) using citric acid to from cross-linked HES-citrate. The HES-citrate as obtained is characterized using FTIR and 1 H NMR. The cross-linked product HES-citrate shows remarkable swelling in different media simulated to the physiological systems of human body, i.e., deionized water (DW), pH 6.8 and 7.4, and followed second order swelling kinetics. The HES-citrate exhibits reversible swelling/deswelling in different combinations of stimuli, i.e., at pH 7.4 and 1.2, in DW and normal saline and in DW and ethanol which makes it a potential candidate for intelligent drug delivery. Therefore, cross-linked product shows extraordinary stimuli-responsiveness under different physiological conditions such as in presence electrolytes and solvents and at different temperatures. HES-citrate-based aceclofenac tablet is formulated that demonstrates sustained-release under conditions mimicked to gastrointestinal tract (GIT) in terms of pH and transit time.

show abstract

“…Fitting of this kinetic model to swelling of HES‐citrate suggested that this material might provide sustained drug release to target the distal part of gastro‐intestinal tract. [ 19 ]…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization, and Stimuli Responsive On/Off Switching of Cross‐Linked Hydroxyethyl Starch: A Smart Material for Intelligent Drug Delivery

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Within the last few decades, the pH-dependent swelling-shrinking induced behavior resulted in the formation of new polysaccharide NPs that received significant interest in drug delivery [77,78]. The stimuliresponsive therapeutics release rely on different interactions induced by the aqueous property, polymeric backbone, and pharmaceutical structural composition [79][80][81][82].…”

Section: Effect Of Phmentioning

confidence: 99%

Current-status and applications of polysaccharides in drug delivery systems

Prasher

Sharma

Mehta

et al. 2021

Colloid and Interface Science Communications

View full text Add to dashboard Cite

The polysaccharide-based advanced drug delivery system owing to their biocompatibility, ability to encapsulate the drug molecules in their interspaces, and ability to achieve a controlled release of the cargo drug molecules result in improved drug pharmacokinetics. The drug-loaded polysaccharides possess ability to evade the multidrug-resistant microbial efflux pumps by aggregation effect, whereas the drug loaded polysaccharidefabricated metal nanoparticles present an exceptional candidature for effectively transporting the drug molecules across the membrane barriers while enabling the theranostic applications at the same time. The biodegradability of polysaccharide based drug delivery systems ensure a sustained release of the encapsulated drug molecules, which minimizes the side effects caused by a burst release of the cargo therapeutics. These drug delivery systems proved highly beneficial for the NSAIDs that otherwise manifest ulcerogenic effect in the gastrointestinal tract. The large surface area of polysaccharides further provide a higher drug-loading capacity, which maintains the optimal concentration of the cargo drug at the target sites. The emerging applications of biodegradable polysaccharides in the designing of multicompartmental microspheres revolutionized tissue engineering, multi drug delivery, and cell culturing technologies. The present review deals with the current-status of polysaccharides as advanced drug delivery systems.

show abstract

“…In the future, cross-linked glucuronoxylan can be designed using CA to keep its swelling response intact for various applications viz. development of stomach-safe oral formulations which can preferentially be used for ulcer patients [18]. Literature reported that the CA is inexpensive, safe, non-toxic, and naturally available.…”

Section: Ca As a Green Crosslinkermentioning

confidence: 99%

Pharmaceutical applications of citric acid

et al. 2021

View full text Add to dashboard Cite

Background Citric acid (CA) is a universal plant and animal-metabolism intermediate. It is a commodity chemical processed and widely used around the world as an excellent pharmaceutical excipient. Notably, CA is offering assorted significant properties viz. biodegradability, biocompatibility, hydrophilicity, safety, etc. Therefore, CA is broadly employed in many sectors including foodstuffs, beverages, pharmaceuticals, nutraceuticals, and cosmetics as a flavoring agent, sequestering agent, buffering agent, etc. From the beginning, CA is a regular ingredient for cosmetic pH-adjustment and as a metallic ion chelator in antioxidant systems. In addition, it is used to improve the taste of pharmaceuticals such as syrups, solutions, elixirs, etc. Furthermore, free CA is also employed as an acidulant in mild astringent preparations. Main text In essence, it is estimated that the functionality present in CA provides excellent assets in pharmaceutical applications such as cross-linking, release-modifying capacity, interaction with molecules, capping and coating agent, branched polymer nanoconjugates, gas generating agent, etc. Mainly, the center of attention of the review is to deliver an impression of the CA-based pharmaceutical applications. Conclusion In conclusion, CA is reconnoitered for multiple novels pharmaceutical and biomedical/applications including as a green crosslinker, release modifier, monomer/branched polymer, capping and coating agent, novel disintegrant, absorption enhancer, etc. In the future, CA can be utilized as an excellent substitute for pharmaceutical and biomedical applications. Graphical abstract

show abstract

Citric acid cross-linked glucuronoxylans: A pH-sensitive polysaccharide material for responsive swelling-deswelling vs various biomimetic stimuli and zero-order drug release

Cited by 18 publications

References 19 publications

Synthesis, Characterization, and Stimuli Responsive On/Off Switching of Cross‐Linked Hydroxyethyl Starch: A Smart Material for Intelligent Drug Delivery

Synthesis, Characterization, and Stimuli Responsive On/Off Switching of Cross‐Linked Hydroxyethyl Starch: A Smart Material for Intelligent Drug Delivery

Current-status and applications of polysaccharides in drug delivery systems

Pharmaceutical applications of citric acid

Contact Info

Product

Resources

About