Citrinin-producing capacity of Monascus purpureus in response to low −frequency magnetic fields

Wan, Yunlei; Zhang, Jialan; Han, Haitang; Li, Li; Liu, Yingbao; Gao, Mengxiang

doi:10.1016/j.procbio.2016.11.009

Cited by 40 publications

(30 citation statements)

References 31 publications

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“…This might be a molecular mechanism by which LF‐MF could reduce citrinin content while enhancing Monascus pigment production. Similar results have been reported by Wan et al [2017]. There also were reports that the magnetic field induced the relative expression levels of genes involved in cell growth, metabolism, oxidative stress response, and protein synthesis [Cambpbell‐Beachler et al, 1998; Polidori et al, 2012].…”

Section: Discussionsupporting

confidence: 86%

“…This reveals that LF‐MF may regulate the secondary metabolism of fungi. For Monascus purpureus , exposure to the LF‐MF could reduce citrinin production and increase yellow and red pigment production of M. purpureus [Zhang et al, 2015; Wan et al, 2017]. It was confirmed that membrane Na, K‐ATPase activity and reaction were stimulated by magnetic fields under optimal conditions [Blank et al, 1995; Blank and Soo, 2001].…”

Section: Introductionmentioning

confidence: 98%

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Low‐Frequency Magnetic Field of Appropriate Strengths Changed Secondary Metabolite Production and Na⁺ Concentration of Intracellular and Extracellular Monascus purpureus

Xiong

Zhen

Liu

et al. 2020

Bioelectromagnetics

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Monascus purpureus is used to yield edible pigments accompanied by mycotoxin-citrinin. A low-frequency (<300 Hz) magnetic field (LF-MF) affects microbial metabolism. The link of LF-MF with secondary metabolites and intracellular and extracellular Na + levels in M. purpureus was determined. The fermentation broth was exposed to LF-MF during the first 2 days of fermentation and continuously cultured at 30°C and 200 rpm until the 8th day of fermentation. Results showed that LF-MF treatments didn't affect the growth of M. purpureus in liquid-state fermentation. Compared with the control, citrinin production showed a decrease of 45.0%, while yellow, red, and orange pigment production showed an increase of 72.9, 73.9, and 40.1%, respectively, with LF-MF treatment of 1.6 mT. This was in agreement with downregulation of pksCT and ctnA, and upregulation of pksPT, pigR, veA, and laeA at the transcriptional level. Moreover, 1.6 mT LF-MF exposure caused the transfer of Na + from extracellular to intracellular, which was validated through the upregulation of transmembrane sensor synthesis genes and the changes in the relative expression levels of the P-type ATPase and protein phosphatase genes. This study established that LF-MF could inhibit citrinin and stimulate pigment production and change intracellular and extracellular Na + concentrations. Bioelectromagnetics. 2020;41:289-297.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 98%

Low‐Frequency Magnetic Field of Appropriate Strengths Changed Secondary Metabolite Production and Na⁺ Concentration of Intracellular and Extracellular Monascus purpureus

Xiong

Zhen

Liu

et al. 2020

Bioelectromagnetics

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“…ELF‐MF increases the citric acid and cellulose production of A. niger [Gao et al, ], mannatide production of α‐hemolytic Streptococcus [Zhang et al, ], and pigment production of Monascus purpureus [Zhang et al, , ]. Moreover, ELF‐MF could decrease citrinin production, a type of mycotoxin, and at the same time, could increase yellow, red, and orange pigment and monacolin K production in M. purpureus [Wan et al, ].…”

Section: Discussionmentioning

confidence: 99%

Global gene expression changes reflecting pleiotropic effects of Irpex lacteus induced by low‐intensity electromagnetic field

Sun

et al. 2019

Bioelectromagnetics

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A polysaccharide of Irpex lacteus, a white‐rot fungus with lignocellulose‐degrading activities, has been used as a commercial medicine for nephritis treatment. Previously, a low‐intensity electromagnetic field (LI‐EMF) was found to increase the biomass and polysaccharide content of Irpex lacteus and induce twists on the cell surface. In this study, RNA‐sequencing (RNA‐seq) technology was used to analyze the underlying mechanism of LI‐EMF's influence on Irpex lacteus. We identified 3268, 1377, and 941 differentially expressed genes (DEGs) in the LI‐EMF‐treated samples at recovery times of 0 h, 3 h, and 6 h, respectively, indicating a significant decline in the influence of the LI‐EMF treatment on Irpex lacteus with the passage of recovery time. Moreover, 30 upregulated and 14 downregulated DEGs overlapped in the LI‐EMF‐treated samples at the recovery times of 0 h, 3 h, and 6 h, implying the important lasting effects of LI‐EMF. The reliability of the RNA‐seq data were validated by quantitative real‐time PCR (qRT‐PCR). The DEGs related to transcription factors, cell proliferation, cell wall, membrane components, amino acid biosynthesis and metabolism, and polysaccharide biosynthesis and metabolism were significantly enriched in the LI‐EMF‐treated samples. The experiments confirmed that the LI‐EMF treatment significantly increased the content of amino acids with a considerable increase in the content of essential amino acids. Therefore, the global gene expression changes explained the pleiotropic effects of Irpex lacteus induced by the LI‐EMF treatment. These findings provide the requisite data for the appropriate design and application of LI‐EMF in the fermentation of microorganisms to increase production. Bioelectromagnetics. 40:104–117, 2019. © 2019 Bioelectromagnetics Society

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“…Tsukahara et al (2009) have reported that increasing culture temperature can effectively increase the yield of pigment and reduce citrinin. Wan et al (2017) proposed that citrinin production could be affected under a low frequency magnetic field. Thirdly, genetic engineering has been used recently to knock out key genes to reduce citrinin.…”

Section: Introductionmentioning

confidence: 99%

Effects of some flavonoids on the mycotoxin citrinin reduction by Monascus aurantiacus Li AS3.4384 during liquid-state fermentation

et al. 2020

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Monascus can produce many beneficial metabolites; however, it can simultaneously also produce citrinin, which seriously limits its application. Therefore, reducing the production of citrinin is of great interest. Herein, Monascus aurantiacus Li AS3.4384 (MAL) was used to optimize the liquid-state fermentation process and investigate the effects of genistein and other flavonoids on citrinin, pigments, and biomass of MAL. Results showed that citrinin decreased by 80%, pigments and biomass increased by approximately 20% in 12 days with addition of 20.0 g/L rice powder as a carbon source and 2.0 g/L genistein during shaking liquid-state fermentation. Further, genistein, daidzein, luteolin, apigenin, quercetin, baicalein, kaempferol myricetin, and genistin exerted different effects on citrinin production by MAL, with genistein causing the highest reduction in citrinin production during liquid-state fermentation, possibly due to the presence of C5-OH, C4′-OH, and C7-OH. Therefore, genistein can be added to the fermentation process of Monascus to reduce citrinin.

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Citrinin-producing capacity of Monascus purpureus in response to low −frequency magnetic fields

Cited by 40 publications

References 31 publications

Low‐Frequency Magnetic Field of Appropriate Strengths Changed Secondary Metabolite Production and Na⁺ Concentration of Intracellular and Extracellular Monascus purpureus

Low‐Frequency Magnetic Field of Appropriate Strengths Changed Secondary Metabolite Production and Na⁺ Concentration of Intracellular and Extracellular Monascus purpureus

Global gene expression changes reflecting pleiotropic effects of Irpex lacteus induced by low‐intensity electromagnetic field

Effects of some flavonoids on the mycotoxin citrinin reduction by Monascus aurantiacus Li AS3.4384 during liquid-state fermentation

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Citrinin-producing capacity of Monascus purpureus in response to low −frequency magnetic fields

Cited by 40 publications

References 31 publications

Low‐Frequency Magnetic Field of Appropriate Strengths Changed Secondary Metabolite Production and Na+ Concentration of Intracellular and Extracellular Monascus purpureus

Low‐Frequency Magnetic Field of Appropriate Strengths Changed Secondary Metabolite Production and Na+ Concentration of Intracellular and Extracellular Monascus purpureus

Global gene expression changes reflecting pleiotropic effects of Irpex lacteus induced by low‐­intensity electromagnetic field

Effects of some flavonoids on the mycotoxin citrinin reduction by Monascus aurantiacus Li AS3.4384 during liquid-state fermentation

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Low‐Frequency Magnetic Field of Appropriate Strengths Changed Secondary Metabolite Production and Na⁺ Concentration of Intracellular and Extracellular Monascus purpureus

Low‐Frequency Magnetic Field of Appropriate Strengths Changed Secondary Metabolite Production and Na⁺ Concentration of Intracellular and Extracellular Monascus purpureus

Global gene expression changes reflecting pleiotropic effects of Irpex lacteus induced by low‐intensity electromagnetic field