Citrobacter koseri meningitis with cerebral edema and pneumocephalus in a neonate

Ward, Hillary Howell; Lauber, Priyanka; Laubach, Lexis T.; Fishbein, Jacob; Greenberg, Marna Rayl

doi:10.1016/j.radcr.2020.12.039

Cited by 3 publications

(2 citation statements)

References 7 publications

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“… 31 There were also Gram-positive bacteria Gleimia europaea , which is also widely present in the human skin microbiota and has been reported to cause brain abscesses. 32 Citrobacter koseri is a Gram-negative bacterium of the family Enterobacteriaceae isolated by hand and commonly found in water, soil, and human intestine, 33 which causes brain abscesses, 34 skeletal muscle, 35 and skin infections 36 in immunocompromised populations such as neonates as a conditional pathogen. The fungi were Exophiala lecanii corni which infects the skin 37 and cornea 38 and Megasphaera elsdenii which causes endocarditis.…”

Section: Discussionmentioning

confidence: 99%

Microbial Community Characterization and Molecular Resistance Monitoring in Geriatric Intensive Care Units in China Using mNGS

Yang,

Li,

Zhu

et al. 2023

IDR

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Background Surface pathogens in the ICU pose a global public health threat, especially to elderly patients who are immunocompromised. To detect these pathogens, unbiased methods such as metagenomic next-generation sequencing (mNGS) are increasingly utilized for environmental microbiological surveillance. Methods In a six-month study from January to July 2022, we investigated microbial communities in Chinese geriatric ICUs by regularly monitoring multiple surfaces at three-month intervals. Using mNGS sequencing, we analyzed microorganisms present at eight specific locations within the ICU. Additionally, we compared pathogen profiles and drug resistance genes between patient cultures and environmental samples collected during the same period. Results The microbial composition remained relatively stable over time, but significant differences in alpha diversities were observed among various surfaces such as floors, hands, pumps, trolleys, and ventilator inlets/outlets. Surfaces with high contact frequency for healthcare workers, including workstations, ventilator panels, trolleys, pumps, and beds, harbored pathogenic microorganisms such as Acinetobacter baumannii , Cutibacterium acnes , Staphylococcus haemolyticus , Pseudomonas aeruginosa , and Enterococcus faecium . Acinetobacter baumannii , particularly the carbapenem-resistant strain (CRAB), was the most frequently identified pathogen in geriatric ICU patients regardless of testing method used. The mNGS approach enabled detection of viruses, fungi, and parasites that are challenging to culture. Additionally, an abundance of drug resistance genes was found in almost all environmental samples. Conclusion The microbial composition and abundance in the ICU remained relatively constant over time. The floor exhibited the highest microbial diversity and abundance in the ICU environment. Drug-resistant genes in the ICU environment may migrate between patients. Overall, mNGS is an emerging and powerful tool for microbiological monitoring of the hospital environment.

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Section: Discussionmentioning

confidence: 99%

Microbial Community Characterization and Molecular Resistance Monitoring in Geriatric Intensive Care Units in China Using mNGS

Yang,

Li,

Zhu

et al. 2023

IDR

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“…In neonates, C. koseri infection is responsible for meningitis, cerebral abscesses, brain adhesions, encephalitis, ventriculitis, and pneumocephalus [ 2 , 3 , 4 , 5 , 6 , 7 ]. The bacterium is acquired from vertical maternal transmission at delivery or through horizontal nosocomial spread, but, in most cases, the origin remains unknown [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Second Trimester Fetal Loss Due to Citrobacter koseri Infection: A Rare Cause of Preterm Premature Rupture of Membranes (PPROM)

et al. 2022

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Citrobacter koseri is a facultative anaerobic, motile, non-spore-forming Gram-negative bacillus, which belongs to the family of Enterobacteriaceae. Severe infections due to Citrobacter spp. have been reported in the urinary tract, respiratory airways, intra-abdominal organs, skin and soft tissue, eye, bone, bloodstream, and central nervous system. In newborns, C. koseri is a well-known cause of meningitis, cerebral abscesses, brain adhesions, encephalitis, and pneumocephalus. Infection can be acquired through vertical maternal transmission or horizontal hospital settings; however, in many cases, the source is unknown. Preterm premature rupture of membranes (PPROM), caused by C. koseri, has rarely been described. Herein, we describe a case of PPROM at 16 weeks and 3 days of gestation, leading to anhydramnios. The parents opted for legal termination of the pregnancy, as the prognosis was very poor. C. koseri was isolated postmortem from a placental subamniotic swab and parenchymal sample, as well as fetal blood and lung. To the best of our knowledge, this is the first case of early second-trimester PPROM in which C. koseri infection was demonstrated.

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Bacterial and Fungal Intracranial Infections

de Vries,

Volpe

2025

Volpe's Neurology of the Newborn

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Citrobacter koseri meningitis with cerebral edema and pneumocephalus in a neonate

Cited by 3 publications

References 7 publications

Microbial Community Characterization and Molecular Resistance Monitoring in Geriatric Intensive Care Units in China Using mNGS

Microbial Community Characterization and Molecular Resistance Monitoring in Geriatric Intensive Care Units in China Using mNGS

Second Trimester Fetal Loss Due to Citrobacter koseri Infection: A Rare Cause of Preterm Premature Rupture of Membranes (PPROM)

Bacterial and Fungal Intracranial Infections

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