Citrulline Can Preserve Proliferation and Prevent the Loss of CD3 ζ Chain Under Conditions of Low Arginine

Bansal, Vishal; Rodríguez, Paulo C.; Wu, Guoyao; Eichler, Duane C.; Zabaleta, Jovanny; Taheri, Faramarz; Ochoa, Juan B.

doi:10.1177/0148607104028006423

Cited by 56 publications

(52 citation statements)

References 33 publications

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“…Additionally, arginase I and iNOS not only compete for arginine but can also inhibit each others activity [26,31,32]. In our experiments, nitrite levels and iNOS expression were up-regulated in PGE 2 stimulated Jurkat cells.…”

Section: Discussionsupporting

confidence: 48%

Arginine is Essential in Reversing Prostaglandin E2 T-Cell Suppression by Hypertonic Saline

Choi

Bansal

Costantini

et al. 2009

Journal of Surgical Research

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Section: Discussionsupporting

confidence: 48%

Arginine is Essential in Reversing Prostaglandin E2 T-Cell Suppression by Hypertonic Saline

Choi

Bansal

Costantini

et al. 2009

Journal of Surgical Research

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“…In line with this, inhibition of arginase in cultured endothelial cells stimulates NO synthesis (26,27), whereas arginase over-expression inhibits NO synthesis (10). It has been suggested that arginase may modulate or down-regulate NOS activity by substrate competition also in macrophages (28) and T-lymphocytes (29). That arginase had some effect in the present study was clear from the increased mean arterial blood pressure, which presumably reflects a disturbance of NO production in some resistance vessels (6).…”

Section: Discussionsupporting

confidence: 80%

Arginase Increases Total Pancreatic and Islet Blood Flow in Anaesthetized Mice

Jansson

Bodin

Källskog

2007

Upsala Journal of Medical Sciences

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Background. Previous studies have demonstrated that the high basal pancreatic islet blood perfusion is crucially dependent on nitric oxide formation. Arginase can interfere with the formation of nitric oxide by limiting substrate availability. The aim of the present study was to evaluate the influence of arginase on islet blood perfusion in anasthetized mice.Methods. The blood perfusion of the pancreatic islets was measured with a microsphere technique in anaesthetized NMRI mice after administration of arginase.Results: Arginase administration increased both total pancreatic and islet blood flow to the same degree. Also adrenal blood flow was increased, whereas other organ blood flow values were unaffected.Conclusion. Arginase induces a paradoxical increase in pancreatic and islet blood flow, the reasons for which are still unknown.

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“…In our experiments arginine in growth medium must have been consumed, at least in part, during medium conditioning due to the strong NO formation of the activated microglia. Furthermore, it is known that arginine depletion upregulates Ass (Bansal et al, 2004). Taken together, this could explain the upregulation of Ass by MCM[1]-treated in contrast to MCM[2]-treated astrocytes and could provide a possible mechanism to sustain arginine supply for the generation of NO by microglia.…”

Section: Discussionmentioning

confidence: 96%

Activated microglia modulate astroglial enzymes involved in oxidative and inflammatory stress and increase the resistance of astrocytes to oxidative stress in Vitro

Röhl

Armbrust

Kolbe³

et al. 2008

Glia

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Neuropathological processes in the central nervous system are commonly accompanied by an activation of microglia and astrocytes. The involvement of both cell populations in the onset and progress of neurological disorders has been widely documented, implicating both beneficial and detrimental influences on the neural tissue. Nevertheless, little is known about the interplay of these glial cell populations, especially under diseased conditions. To examine the effects of activated microglia on astrocytes purified rat astroglial cell cultures were treated with medium conditioned by purified quiescent (MCM[-]) or lipopolysaccharide (LPS)-activated rat microglia (MCM[+]) and subjected to a comparative proteome analysis based on two-dimensional gel electrophoresis. No significant down regulation of proteins was observed. The majority of the 19 proteins identified by means of nano HPLC/ESI-MS/MS in the 12 most prominent protein spots significantly overexpressed (> or =2-fold) in MCM[+] treated astrocytes are involved in inflammatory processes and oxidative stress response: superoxide dismutases (Sod), peroxiredoxins, glutathione S-transferases (Gst), nucleoside diphosphate kinase B, argininosuccinate synthase (Ass), and cellular retinol-binding protein I (Rbp1). Sod2, Rbp1, Gstp1, and Ass were also significantly increased on the mRNA level determined by quantitative RT-PCR. The upregulation of antioxidative enzymes in astrocytes was accompanied by a higher resistance to oxidative stress induced by H2O2. These results show that activated microglia change the expression of antioxidative proteins in astrocytes and protect them against oxidative stress, which might be an effective way to increase the neuroprotective potential of astrocytes under pathological conditions associated with oxidative stress and inflammation.

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Citrulline Can Preserve Proliferation and Prevent the Loss of CD3 ζ Chain Under Conditions of Low Arginine

Cited by 56 publications

References 33 publications

Arginine is Essential in Reversing Prostaglandin E2 T-Cell Suppression by Hypertonic Saline

Arginine is Essential in Reversing Prostaglandin E2 T-Cell Suppression by Hypertonic Saline

Arginase Increases Total Pancreatic and Islet Blood Flow in Anaesthetized Mice

Activated microglia modulate astroglial enzymes involved in oxidative and inflammatory stress and increase the resistance of astrocytes to oxidative stress in Vitro

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