Citrulline supplementation improves spatial memory in a murine model for Alzheimer's disease

Martínez-González, Katia; Serrano-Cuevas, Leonor; Almeida-Gutiérrez, Eduardo; Flores-Chavez, Salvador; Mejı́a-Aranguré, Juan Manuel; García-delaTorre, Paola

doi:10.1016/j.nut.2021.111248

Nutrition

2021

DOI: 10.1016/j.nut.2021.111248

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Citrulline supplementation improves spatial memory in a murine model for Alzheimer's disease

Katia Martínez-González

Leonor Serrano-Cuevas

Eduardo Almeida-Gutiérrez

et al.

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Cited by 5 publications

(1 citation statement)

References 69 publications

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“…The CIT level in dogs with CDV has not been previously studied. Experimentally, CIT supplementation in patients with Alzheimer’s disease improves spatial memory and increases the level of ARG in the cerebrospinal fluid [ 35 ]. This finding indicates that it is worth investigating CIT levels as it may offer new treatment options against CDV as it shows neurovirulence to the central nervous system resulting in poor prognosis and even euthanasia, especially when neurological symptoms begin.…”

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Comparison of some cytokines, acute phase proteins and citrulline levels in healthy and canine distemper infected dogs

Dik

Hatipoğlu

Gülersoy

2023

The Journal of Veterinary Medical Science

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Canine distemper virus (CDV) is the etiological agent of severe disease in domestic and wild carnivores. Clinical diagnosis of CDV is challenging because of its similarity to other canine respiratory and intestinal diseases. We aimed to determine certain cytokine (interleukin [IL]-1β, IL-2, IL-4, IL-6, IL-10, and tumor necrosis factor-α [TNF-α]), interferon (IFN)-γ, canine serum amyloid A (SAA), and canine citrulline (CIT) levels for the first time in CDV-positive dogs. For this purpose, 10 CDV-positive dogs with compatible clinical findings (i.e., neurological symptoms such as tremors and myoclonus, ocular and nasal discharge, and wheezing) and 10 healthy dogs based on the clinical examinations and rapid test results were enrolled. It was observed that the CIT, INF-γ, IL-1β, IL-2, IL-6, and TNF-α levels were significantly decreased in the CDV-positive dogs than that of the healthy ones (P<0.05). As a result, it was observed that CDV causes immunosuppression and accordingly, the inflammatory response might cause decreased cytokine and acute-phase protein synthesis. Therefore, it was concluded that further investigation of inflammatory pathways and CIT interactions may provide crucial clinical information at different stages of CDV, and aforementioned parameters may serve as important biomarkers for CDV in terms of demonstrating the presence of immunosuppression.

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Comparison of some cytokines, acute phase proteins and citrulline levels in healthy and canine distemper infected dogs

Dik

Hatipoğlu

Gülersoy

2023

The Journal of Veterinary Medical Science

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Pentachlorophenol exposure induced neurotoxicity by disrupting citrulline metabolism in larvae and adult zebrafish

Zhang,

Li,

Zhu

et al. 2023

Toxicology and Applied Pharmacology

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Impact of supplementation with L-citrulline/arginine after liver transplantation in individuals with Urea Cycle Disorders

Posset,

Garbade,

Gleich

et al. 2024

Molecular Genetics and Metabolism

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Citrulline supplementation improves spatial memory in a murine model for Alzheimer's disease

Cited by 5 publications

References 69 publications

Comparison of some cytokines, acute phase proteins and citrulline levels in healthy and canine distemper infected dogs

Comparison of some cytokines, acute phase proteins and citrulline levels in healthy and canine distemper infected dogs

Pentachlorophenol exposure induced neurotoxicity by disrupting citrulline metabolism in larvae and adult zebrafish

Impact of supplementation with L-citrulline/arginine after liver transplantation in individuals with Urea Cycle Disorders

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