Citrullus colocynthis an Important Plant in Indian Traditional System of Medicine

Kapoor, Manish; Kaur, Navneet; Sharma, Chanchal; Kaur, Gurpreet; Kaur, Rupinder; Batra, Kajal; Rani, Jyoti

doi:10.5530/phrev.2020.14.4

Cited by 34 publications

(19 citation statements)

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“…Surprisingly, some of the mentioned therapies use an emetic and claim that the victim would vomit out snake venom, which is practically unjustifiable [9] (pp. 15,124,260), [20] (V. 1, p. 54) (V. 5, p. 357). Only orally ingested poisons can be thrown out via emesis to avoid further entry into the systemic circulation.…”

Section: Therapeutic Anomaliesmentioning

confidence: 99%

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A Contemporary Exploration of Traditional Indian Snake Envenomation Therapies

Adwait¹,

Sastry²,

Bhise³

2022

TropicalMed

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Snakebite being a quick progressing serious situation needs immediate and aggressive therapy. Snake venom antiserum is the only approved and effective treatment available, but for selected snake species only. The requirement of trained staff for administration and serum reactions make the therapy complicated. In tropical countries where snakebite incidence is high and healthcare facilities are limited, mortality and morbidities associated with snake envenomation are proportionately high. Traditional compilations of medical practitioners’ personal journals have wealth of plant-based snake venom antidotes. Relatively, very few plants or their extractives have been scientifically investigated for neutralization of snake venom or its components. None of these investigations presents enough evidence to initiate clinical testing of the agents. This review focuses on curating Indian traditional snake envenomation therapies, identifying plants involved and finding relevant evidence across modern literature to neutralize snake venom components. Traditional formulations, their method of preparation and dosing have been discussed along with the investigational approach in modern research and their possible outcomes. A safe and easily administrable small molecule of plant origin that would protect or limit the spread of venom and provide valuable time for the victim to reach the healthcare centre would be a great lifesaver.

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Section: Therapeutic Anomaliesmentioning

confidence: 99%

“…Fruits ˆ [118] Fruits ~ [122,123] None Fruits [124] Roots, Fruits [125] Roots, Fruits, Seeds [126,127] Methanolic extract of the whole plant of Citrullus colocynthis neutralized haemorrhage induced by Naja naja karachiensis snake venom [128].…”

Section: Caesalpiniaceaementioning

confidence: 99%

A Contemporary Exploration of Traditional Indian Snake Envenomation Therapies

Adwait¹,

Sastry²,

Bhise³

2022

TropicalMed

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“…Colocynth or Bitter Apple is the popular name for the fruit of C. colocynthis. 15 Alkaloids, tannins, saponins, flavonoids, unsaturated sterols, oxygenated terpenes, sterols, and steroids were found in a hydro-methanolic extract of the fruit. Fruit extracts contained cucurbitacins, colocynthosides, and flavonoids glucosides such as isovitixin, isorintin, and isosapanorin.…”

Section: Introductionmentioning

confidence: 98%

Investigation of Neuroprotective and Antiparkinson’s Activity of Citrullus colocynthis Fruit

Nimra¹,

Fatima²

2021

JDVAT

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“…It contains one of the outstanding collections of the genetically diversified organisms in the kingdom of plants. A large number of plants of this family are drought tolerant, susceptible to flooding, cold season and resistant to harshness of barren lands (Dhakad et al, 2017;Kapoor et al, 2020). Citrullus colocynthis plant is an herb which shows perennial mode of life.…”

Section: Introductionmentioning

confidence: 99%

“…The importance of C. colocynthis plant is disclosed in certain studies as it has various medicinal effects. Anti-inflammatory effect (Onyeji et al, 2017), antioxidative effect (Bernard and Olayinka, 2010), anticonvulsant effect (Kaushik et al, 2015;Mehrzadi et al, 2016), anti-alopecia effect (Dhanotia et al, [Citation: Hameed, B., Ali, Q., Hafeez, M.M., Malik, A. (2020).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and Antifungal Activity of Fruit, Seed and Root Extracts of Citrullus Colocynthis Plant

Hameed

Ali

Hafeez

et al. 2020

Biol Clin Sci Res J

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Gastrointestinal, skin, pulmonary and cardiovascular problems have been reported all over the world on massive scale. The treatment of these problems has become tough due to genetically modified bacterial strains and fungal infections. The present studied was conducted to evaluate the antimicrobial activities of Citrullus colocynthis plant extract. The ethanolic extract of dried fruit pulp, seed, and root was evaluated with respect to anti-bacterial and anti-fungal properties. The anti-microbial profile studied against four bacterial strains (2 Gram negative and 2 Gram positive) while anti-fungal profile studied against four fungal species. All the bacterial and fungal strains used in the study showed sensitivities against the respective extracts. The zones of inhibition ranged between 7 mm to 23 mm, and 6 mm to 23 mm in against bacterial and fungal strains, respectively. The extract of seed found to be less effective against both the organisms. It was suggested from our study that the extract of Citrullus colocynthis may be used in medicines to cure bacterial diseases.

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Citrullus colocynthis an Important Plant in Indian Traditional System of Medicine

Cited by 34 publications

References 0 publications

A Contemporary Exploration of Traditional Indian Snake Envenomation Therapies

A Contemporary Exploration of Traditional Indian Snake Envenomation Therapies

Investigation of Neuroprotective and Antiparkinson’s Activity of Citrullus colocynthis Fruit

Antibacterial and Antifungal Activity of Fruit, Seed and Root Extracts of Citrullus Colocynthis Plant

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