Modern greenhouses are intensive farming systems designed to achieve high efficiency and productivity. Plants are produced year-round in greenhouses by maintaining the environment at or near optimum levels regardless of extreme weather conditions. Many scientific discoveries and technological advancements that happened in the past two centuries paved the way for current state-of-the-art greenhouses. These include, but are not limited to, advancements in climate-specific structural designs and glazing materials, and temperature control, artificial lighting, and hydroponic production systems. Greenhouse structures can be broadly grouped into four distinct designs, including tall Venlo greenhouses of the Netherlands, passive solar greenhouses of China, low-cost Parral greenhouses of the Mediterranean region, and gutter-connected polyethylene houses of India and African countries. These designs were developed to suit local climatic conditions and maximize the return on investment. Although glass and rigid plastic options are available for glazing, the development of low-cost and lightweight plastic glazing materials (e.g., polyethylene) enabled widespread growth of the greenhouse industry in the developing world. For temperate regions, supplemental lighting technology is crucial for year-round production. This heavily relies on advancements in electro-lighting during the 19th and 20th centuries. The development of hydroponic production systems for the controlled delivery of nutrients further enhanced crop productivity. This article addresses important historical events, scientific discoveries, and technological improvements related to advancements in these areas.