Citrus Juices Health Benefits

Cancalon, Paul

doi:10.1007/978-3-319-23672-8_8

Cited by 3 publications

(1 citation statement)

References 54 publications

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“…Many studies have been shown the valuable antiosteoporotic effects of some citrus fruits components; however these studies didn't clarify the mechanistic pathways (Zhang et al 2014;Cancalon 2016;Singh et al 2018).…”

Section: Discussionmentioning

confidence: 99%

Grapefruit juice exerts anti-osteoporotic activities in a prednisolone-induced osteoporosis rat femoral fracture model, possibly via the RANKL/OPG axis

et al. 2019

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This study aimed to shed light on the protective and therapeutic anti-osteoporotic effects and mechanisms of action of grapefruit juice (GFJ) on prednisolone-induced osteoporosis a rat femoral fracture model. We found that treating rats with GFJ before and/or after prednisolone-induced osteoporosis resulted in increased bone density, total mineral content, and calcium content to counteract the osteoporotic effects of prednisolone. In parallel, the histological and ultrastructural results of the GFJ-treated groups correlated well with enhanced breaking strength of femurs subjected to a constant load. Furthermore, GFJ treatment before and after prednisolone-induced osteoporosis decreased plasma alkaline phosphatase and tartrate-resistant acid phosphatase activities and increased the level of insulin-like growth factor 1. Mechanistically, our immunohistochemistry study showed that GFJ ameliorated prednisolone-induced osteocalcin depletion, decreased receptor activator of nuclear factor kappa-B

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Section: Discussionmentioning

confidence: 99%