Citrus pectin attenuates endotoxin shock via suppression of Toll-like receptor signaling in Peyer's patch myeloid cells

Ishisono, Keita; Yabe, Tomio; Kitaguchi, Kohji

doi:10.1016/j.jnutbio.2017.07.016

Cited by 62 publications

(50 citation statements)

References 41 publications

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“…However, when this study was performed using polygalacturonic acid, treatment was not effective, highlighting the importance of neutral sugars present in side chains of pectin. 32 Pacheco et al 6 studied the expression of the inflammatory cytokine panel in the DSSmodel of mice colitis, which was reduced after the administration of CP and orange by-products. These results agree with our study where a similar reduction in pro-inflammatory cytokine expression was observed for AP pectin and APwA, corroborating its immunostimulatory potential.…”

Section: Discussionmentioning

confidence: 99%

Intestinal anti-inflammatory effects of artichoke pectin and modified pectin fractions in the dextran sulfate sodium model of mice colitis. Artificial neural network modelling of inflammatory markers

et al. 2019

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Section: Discussionmentioning

confidence: 99%

Intestinal anti-inflammatory effects of artichoke pectin and modified pectin fractions in the dextran sulfate sodium model of mice colitis. Artificial neural network modelling of inflammatory markers

et al. 2019

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“…Several studies have also reported that citrus pectin directly affects immune cells to regulate inflammatory responses. Citrus pectin is linked with alleviation in the endotoxin-induced pro-inflammatory responses, shown via in vitro and in vivo studies [26,92].…”

Section: Citrus Fruitsmentioning

confidence: 99%

Bioactives from Agri-Food Wastes: Present Insights and Future Challenges

2020

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Sustainable utilization of agri-food wastes and by-products for producing value-added products (for cosmetic, pharmaceutical or food industrial applications) provides an opportunity for earning additional income for the dependent industrial sector. Besides, effective valorisation of wastes/by-products can efficiently help in reducing environmental stress by decreasing unwarranted pollution. The major focus of this review is to provide comprehensive information on valorisation of agri-food wastes and by-products with focus laid on bioactive compounds and bioactivity. The review covers the bioactives identified from wastes and by-products of plants (fruits, exotic fruits, vegetables and seeds), animals (dairy and meat) and marine (fish, shellfish seaweeds) resources. Further, insights on the present status and future challenges of sustainably utilizing agri-food wastes/by-products for value addition will be highlighted.

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“…Furthermore, authors found that the administration of lowmethoxylated pectin from lemon prevented intestinal inflammation in vivo in a fermentation-independent manner. Notably, similar TLR-inhibitory effects are in agreement with in vivo studies using low-and high-methoxylated citrus pectin, which attenuated both endotoxin shock through a TLR-dependent pathway [130], as well as inflammatory effects in a colitis model [131].…”

Section: Toll-like Receptors (Tlr)supporting

confidence: 83%

“…Most of studies focused in the interaction between NDP from plant-source foods and TLR, but we will also describe some recent findings regarding the effects of NDC from foods through NLR-and CLR-dependent pathways. TLR2 Maltooligosaccharides Wheatgrass Activation in immune cells [126] TLR2 and 4 FOS Rice Induction of dendritic cell maturation in mice [127] TLR2 and 4 HG (varying degree of ME) Lemon Activation in T84 cells, maintenance of intestinal epithelial barrier integrity [128] TLR2 and 5 RS3 Maize Activation in HEK cells, NF-κB release [125] TLR2, 3, 5, 9 HG, RG-II, AG-II and HC Papaya (ripe) Activation in HEK cells, NF-κB release [121] TLR2, 3, 9 HG, RG-II, AG-II and HC Papaya (unripe) Activation (TLR2) or inhibition (TLR3 and TLR9) in HEK cells [121] TLR4 Galactan Apple Inhibition of LPS-induced activation in a colitis model [129] TLR4 HG (varying degree of ME) Citrus Inhibition of LPS-induced activation in a colitis model [130,131] TLR4 HG (branched) Citrus Inhibition in immune cells [130] Continue...…”

Section: Pattern Recognition Receptor-mediated Effectsmentioning

confidence: 99%

Structural-dependent effects of dietary fibers in colon cancer: Focus on dietary fiber naturally changed by the papaya ripening

Prado¹

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PRADO, S. B. R. Structural-dependent effects of dietary fibers in colon cancer: Focus on dietary fiber naturally changed by the papaya ripening. 2019. 327f. Tese (Doutorado) -Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, 2019.Dietary fiber (DF) consumption is related with several healthy benefits such as the decreasing risk of colon cancer development. The DF is not digested by the digestive enzymes and reach to colon where is fermented by the colonic microbiota. The fermentation process releases metabolites as short chain fatty acids (SCFA)such as butyrate, propionate and acetate. Besides the fermentation process, the DF can directly interact with intestinal epithelial cells inducing mechanism that can also be related with the associated DF consumption benefits. The lack of information regarding DF and colon cancer are due to the complexity of both the cancer and the DF structure. The papayas DF are derived from the fruit cell wall, and they are probably naturally modified during ripening through a massive polysaccharide hydrolysis, because papayas show a very fast pulp softening. Due to the lack of information about DF and their beneficial effects to human health as well as the possibility of the natural papaya ripening to modifying the DF presented in the fruit pulp, the present thesis had as the primary objectives: 1) to evaluate how the cell-wall degrading enzymes affect the fruit cell wall solubilization and molecular weight; 2) to investigate the direct effects of the papaya pectin derived from unripe to ripe papayas in cancer cell lines, in galectin-3 interaction and in HEK cells expressing pattern recognition receptors (PRR); 3) to evaluate the human colonic in vitro fermentation using DF from unripe and ripe papayas as substrates; 4) to conduct an in vivo experiment using rats with pre-neoplastic colon lesions while receiving a diet with DF from unripe and ripe papayas. The endopolygalacturonases were the main enzymes acting on the solubilizing papaya cell wall pectin affecting both the papaya firmness and pectin structure. Overall, the papayas DF showed a ripening dependent structure-effects. In the cancer cell lines experiments, the ripe papayas pectin showed a more pronounced effects in inducing cancer cell death, inhibiting cancer cells migration and aggregation, activating PRR as toll-like receptors and inhibiting the prometastatic protein galectin-3. The DF from papayas also showed different aspects in colonic in vitro fermentation regarding the DF utilization by the bacteria and the bacteria abundance profile. Lastly, the animals receiving the diet with the DF from ripe papayas had less aberrant crypt foci in colon than the animals that received the DF from unripe papayas or cellulose (AIN-93G DF). Therefore, the study of papaya DF was carried out both during papaya ripening and its biological effects in vitro and in vivo, generating unprecedented results relating the endogenous biochemical changes of the fruits during maturation with the possible beneficial effects o...

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Citrus pectin attenuates endotoxin shock via suppression of Toll-like receptor signaling in Peyer's patch myeloid cells

Cited by 62 publications

References 41 publications

Intestinal anti-inflammatory effects of artichoke pectin and modified pectin fractions in the dextran sulfate sodium model of mice colitis. Artificial neural network modelling of inflammatory markers

Intestinal anti-inflammatory effects of artichoke pectin and modified pectin fractions in the dextran sulfate sodium model of mice colitis. Artificial neural network modelling of inflammatory markers

Bioactives from Agri-Food Wastes: Present Insights and Future Challenges

Structural-dependent effects of dietary fibers in colon cancer: Focus on dietary fiber naturally changed by the papaya ripening

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