Citrus polyphenol for oral wound healing in oral ulcers and periodontal diseases

Tsai, Hsiao-Cheng; Li, Yi‐Chen; Young, Tai‐Horng; Chen, Min-Huey

doi:10.1016/j.jfma.2015.01.003

Cited by 10 publications

(6 citation statements)

References 42 publications

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“…During dental applications of the polyphenolic compounds of these species have shown that these compounds are improved oral wound healing. Therefore, these polyphenols could be used as a supplemental compounds in mouthwash for periodontal diseases to improve wound healing in the mouth [24,25].…”

Section: Citrus Aurantifolia Swing (Rutaceae)mentioning

confidence: 99%

Herbal Extracts Used in Dental Disorders

Şener¹

2019

BJSTR

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Natural products have been recently investigated more thoroughly as promising agents for the prevention of oral diseases, especially plaque-related diseases such as dental caries. Oral diseases, a major health issue in the world, are economically affecting people of developed countries as 10 % of the health expenditure is related to dental care. Different surveys showed that medicinal plant species used by the people for the traditional treatment of dental diseases are inadequately screened for their therapeutic/ preventive potential and phytochemical findings. In this review, some herbal extracts commonly used in dental disorders and their bioactivities are outlined.

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Section: Citrus Aurantifolia Swing (Rutaceae)mentioning

confidence: 99%

Herbal Extracts Used in Dental Disorders

Şener¹

2019

BJSTR

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“…Another study found that using polyphenols improved wound healing in oral sores and periodontitis [ 8 ]. Wound healing occurs following disruption or damage to the normal anatomical structure and function and depends on the power of tissue regeneration, resulting in a coordinated series of cellular and molecular processes including hemostasis, inflammation, proliferative phase, angiogenesis, wound contracture, epithelialization, and matrix remodeling [ 9 ].These processes depend on homogenous functions of neutrophils, macrophages, fibroblasts, and endothelial cells that are controlled by the interaction with other cells, extracellular matrix proteins, and growth factors.…”

Section: Introductionmentioning

confidence: 99%

UPLC-PDA-MS/MS Profiling and Healing Activity of Polyphenol-Rich Fraction of Alhagi maurorum against Oral Ulcer in Rats

El-Zahar

Menze

Handoussa

et al. 2022

Plants

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Camelthorn, Alhagi maurorum Boiss, family Fabaceae has long been used in African folk medicine owing to its richness in pharmacologically active metabolites. The crude extract (CEAM), ethyl acetate fraction (EFAM) and n-butanol (BFAM) fraction of A. maurorum aerial parts were investigated for their total polyphenols and oral antiulcer activity using in-vitro and in-vivo models. The major phenolic compound was isolated from the polyphenol-rich EFAM fraction and identified by conventional and spectroscopic methods of analysis as isorhamnetin-3-O-rutinoside. Furthermore, standardization of EAFM using UPLC-PDA-UV quantified isorhamnetin-3-O-rutinoside as 262.91 0.57 g/mg of the fraction. Analysis of EFAM using UPLC-PDA-MS/MS revealed tentative identification of 25 polyphenolic compounds. EFAM exhibited the most potent free radical scavenging activity against DPPH, with an IC50 (27.73 ± 1.85 μg/mL) and an FRAP value of (176.60 ± 5.21 μM Trolox equivalent (TE)/mg fraction) in comparison with CEAM and BFAM. Acetic acid-induced oral ulcers in a rat model were used to evaluate the healing properties of A. maurorum aerial parts. EFAM significantly decreased tumor necrosis factor-alpha (TNF-α) and interleukin-2 (IL-2) by 36.4% and 50.8%, respectively, in the ulcer tissues while, CEAM and BFAM exhibited lower activity at the same dose. In addition, EFAM led to a significant (p < 0.0001) rise in the expression of proliferating cell nuclear antigen (PCNA), a cell proliferation marker. A. maurorum exhibited a potent healing effect in acetic acid-induced oral ulcers in rats by mitigating the release of pro-inflammatory cytokines and improving PCNA expression.

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“…Various studies were carried out to evaluate the antioxidant and anti-inflammatory capacity of plants on oral ulcer healing and many of them had been published (12)(13)(14). Piper sarmentosum is one of the herbaceous plants which can be found growing abundantly around Southeast Asian countries including Malaysia.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Piper Sarmentosum Aqueous Extract on Buccal Ulcer Healing

2019

JUMMEC

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Oral ulcer is a lesion with multifactorial causes and occurs worldwide. The lesion usually resolved within 14 days, but the pain may have an impact on the quality of patient's life. Therefore, having a natural derived remedy that can reduce healing time would be a great advantage. This study aims to investigate histological sections of buccal ulcer on rats treated with aqueous extract of Piper sarmentosum (AEPS). Glacial acetic acid was used to induce buccal ulcer on male Sprague Dawley rats. Control group received normal saline while the experimental group received AEPS for treatment. On certain days of post-ulcer induction, buccal ulcer tissue samples were harvested, sectioned and stained with Hematoxylin and Eosin (H&E). Histological slides were examined for inflammation and scored. The inflammation severity reduced from day 2 to day 12. In the experimental group there was a statistically significant differences of inflammation score, particularly on day 2 with a score of (2.8 + 0.2). Neutrophils were less in the experimental group and the tissue debris clearance was faster compared to control group. Full reepithelization was observed on both treated tissue sections on day 12 with less severe inflammation. Topical application of AEPS is proven to have anti-inflammatory effect by reducing the number of neutrophils during inflammation phase of oral ulcer healing.

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Citrus polyphenol for oral wound healing in oral ulcers and periodontal diseases

Abstract: The results confirm the feasibility of CP be a supplemental compound in mouthwash for treatment of periodontal diseases in dental application to improve wound healing in the mouth.

Cited by 10 publications

References 42 publications

Herbal Extracts Used in Dental Disorders

Herbal Extracts Used in Dental Disorders

UPLC-PDA-MS/MS Profiling and Healing Activity of Polyphenol-Rich Fraction of Alhagi maurorum against Oral Ulcer in Rats

The Effect of Piper Sarmentosum Aqueous Extract on Buccal Ulcer Healing

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