In this paper, based on electrical power consumption (EPC) data extracted from DMSP/OLS night light data, we select three national-level urban agglomerations in China’s Yangtze River Economic Belt(YREB), includes Yangtze River Delta urban agglomerations(YRDUA), urban agglomeration in the middle reaches of the Yangtze River(UAMRYR), and Chengdu-Chongqing urban agglomeration(CCUA) as the research objects. In addition, the coefficient of variation (CV), kernel density analysis, cold hot spot analysis, trend analysis, standard deviation ellipse and Moran’s I Index were used to analyze the Spatio-temporal Dynamic Evolution Characteristics of EPC in the three urban agglomerations of the YREB. In addition, we also use geographically weighted regression (GWR) model and random forest algorithm to analyze the influencing factors of EPC in the three major urban agglomerations in YREB. The results of this study show that from 1992 to 2013, the CV of the EPC in the three urban agglomerations of YREB has been declining at the overall level. At the same time, the highest EPC value is in YRDUA, followed by UAMRYR and CCUA. In addition, with the increase of time, the high-value areas of EPC hot spots are basically distributed in YRDUA. The standard deviation ellipses of the EPC of the three urban agglomerations of YREB clearly show the characteristics of “east-west” spatial distribution. With the increase of time, the correlations and the agglomeration of the EPC in the three urban agglomerations of the YREB were both become more and more obvious. In terms of influencing factor analysis, by using GWR model, we found that the five influencing factors we selected basically have a positive impact on the EPC of the YREB. By using the Random forest algorithm, we found that the three main influencing factors of EPC in the three major urban agglomerations in the YREB are the proportion of secondary industry in GDP, Per capita disposable income of urban residents, and Urbanization rate.