Industry 5.0 acceptance is accelerating, but research is still in its infancy, and existing research covers a small subset of context-specific obstacles. This study aims to enumerate all potential obstacles, quantitatively rank them, and assess interdependencies at the organizational level for Industry 5.0 adoption. To achieve this, we thoroughly review the literature, identify obstacles, and investigate causal relationships using a multi-criteria decision-making approach called single value Neutrosophic TODIM. Single-valued Neutrosophic sets (SVNS) ensembles are employed in a real-world setting to deal with uncertainty and indeterminacy. The suggested strategy enables the experts to conduct group decision-making by focusing on ranking the smaller collection of criterion values and the comparison with the decision-making trial and evaluation laboratory method (DEMATEL). According to the findings, the most significant hurdles are expenses and the funding system, capacity scalability, upskilling, and reskilling of human labor. As a result, a comfortable atmosphere is produced for decision-making, enabling the experts to handle an acceptable amount of data while still making choices.