In an increasingly digitalized and globalized era, it is vital to promote research and innovation in higher education institutions to have the ability to effectively manage knowledge and take advantage of Information and Communication Technologies (ICT). Therefore, the combination of these tools is essential to improve efficiency, encourage collaboration and facilitate the dissemination of knowledge in the university environment. The present study focuses on analyzing knowledge management and the use of ICT in the research groups of the University of La Guajira, located in Colombia. In theoretical terms, various sources are used such as M.A. Soto Balbón, N.M. Barrios Fernández (2015), Cabero (2015), Carneiro (2009), among other relevant authors. The research approach is descriptive, with a non-experimental and field design, of a transectional type. The sample included 80 directors belonging to categorized and uncategorized research groups, covering a complete population census. A questionnaire was used with 20 dichotomous items and five response options. The results indicated that the members of the research groups have access to the ICT infrastructure and show adequate management of it. Furthermore, the fundamental role of networks for the transfer of knowledge is highlighted, placing this aspect at a moderate level of effectiveness