Civatte bodies: A diagnostic clue

Tanwar, Pranay; Kumar, Avneesh; Chhabra, Seema

doi:10.4103/0019-5154.113974

Cited by 13 publications

(2 citation statements)

References 10 publications

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“…On the contrary, hyperpigmented lesions show increased melanin deposition in the basal layer, melanin incontinence, and melanophages in the upper dermis (Figure 10a,b). 1 A case of DUH with lichenoid reaction in the papillary dermis with Civatte bodies has also been reported 28 . Giant pigment granules (GPGs) that stain dark brown with hematoxylin–eosin stain and black with ammoniated silver nitrate are seen in the epidermis and dermis 3 .…”

Section: Investigationsmentioning

confidence: 99%

“…1 A case of DUH with lichenoid reaction in the papillary dermis with Civatte bodies has also been reported. 28 Giant pigment granules (GPGs) that stain dark brown with hematoxylin-eosin stain and black with ammoniated silver nitrate are seen in the epidermis and dermis. 3 GPGs were earlier considered macro melanosomes but they represent either autolysosomes or complete degradation products of melanosomes.…”

Section: Investigationsmentioning

confidence: 99%

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Dyschromatosis universalis hereditaria

Murthy,

Palaniappan,

Karthikeyan

et al. 2023

Int J Dermatology

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Reticulate pigmentary dyschromatoses primarily include dyschromatosis universalis hereditaria (DUH), dyschromatosis symmetrica hereditaria (DSH) (Reticulate acropigmentation of Dohi), and unilateral dermatomal pigmentary dermatosis, which differ in their patterns of distribution. The disease was initially described by Ichikawa and Hiraga in Germany in 1933. The prevalence of DUH is 0.3 per 100,000 with a female preponderance. The skin lesions usually appear in infancy or early childhood and cease to progress beyond adolescence. The subtypes DUH 1 and DUH 3 are found to have autosomal dominant inheritance, which is the most common inheritance pattern, while DUH 2 has an autosomal recessive pattern. The most common gene involved in DUH is ABCB6, while the other genes include SASH 1, PER 3, and KITLG (DUH type 2). DUH is characterized by multiple irregular hyperpigmented macules interspersed with hypopigmented macules in a mottled pattern over the trunk and extremities. The face is involved in 50% of individuals. Rarely, it can also involve hairs, nails, mucous membranes, palms, and soles. Other varied presentations include localized forms, localization of lesions to sun‐exposed areas, large macules, uniform palmar hypopigmentation, diffuse hyperpigmentation with spotty depigmented macules, and unilateral involvement. DUH has been reported to be associated with various cutaneous and systemic diseases. The authors have observed cases of DUH associated with hepatocellular carcinoma, solitary keratoacanthoma, and dermoid cyst. The various diagnostic modalities include dermoscopy, histopathology, electron microscopy, and targeted gene sequencing. Though various treatment modalities like NBUVB and lasers have been tried, no treatment is promising.

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Section: Investigationsmentioning

confidence: 99%

Section: Investigationsmentioning

confidence: 99%

Dyschromatosis universalis hereditaria

Murthy,

Palaniappan,

Karthikeyan

et al. 2023

Int J Dermatology

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Dyschromatosis

Samuelov¹,

Sprecher²

2019

Harper's Textbook of Pediatric Dermatology

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Immunofluorescence and histopathological assessment using ex vivo confocal laser scanning microscopy in lichen planus

Bağcı

Aoki²,

Krammer³

et al. 2020

Journal of Biophotonics

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Ex vivo confocal laser scanning microscopy (CLSM) provides rapid, high-resolution imaging, fluorescence detection and digital haematoxylineosin (H&E)-like staining. We aimed to assess the performance of ex vivo CLSM in identifying histomorphology and immunoreactivity in lichen planus (LP) and comparing its accuracy with conventional histopathology and direct immunofluorescence (DIF). Thirtythree sections of 17 LP patients stained with acridine orange (AO) and FITClabelled anti-fibrinogen antibody and 21 control samples stained with AO were examined using ex vivo CLSM. Ex vivo CLSM was in perfect agreement with conventional histopathology in identifying interface dermatitis, vacuolar degeneration and band-like infiltration. ROC analysis showed that the presence of vacuolar degeneration, interface dermatitis and band-like infiltration was useful to distinguish LP sections from controls (p < .0001). The detection rates of fibrinogen deposition using DIF and in conclusion ex vivo CLSM were 93.8% and 62.5%, respectively. ex vivo CLSM enables histopathological and immunofluorescence examination in LP with the advantage of digital H&E-like staining.

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Civatte bodies: A diagnostic clue

Cited by 13 publications

References 10 publications

Dyschromatosis universalis hereditaria

Dyschromatosis universalis hereditaria

Dyschromatosis

Immunofluorescence and histopathological assessment using ex vivo confocal laser scanning microscopy in lichen planus

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