CKD in African Americans as a Complex Intertwining of Biology and Socioeconomics: An Introduction

Kövesdy, Csaba P.

doi:10.1053/j.ajkd.2018.06.019

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…While the rate of germline BRCA1/2 mutations in patients with breast cancer is similar across racial/ ethnic groups; obesity, higher parity, younger age at rst birth, and early weaning or never-having breast fed are more prevalent among AA than white women and may signi cantly contribute to increased in ammation and to higher TNBC incidence in AA women [9,10]. This chronic low-grade in ammation is a complex immune response may play an important role in the pathogenesis of multiple chronic diseases, which are more prevalent among the AA population [9,[12][13][14]. Even though several pathways have been identi ed for chronic low-grade in ammation and candidate loci have been proposed [12], the contribution of sociodemographic factors and lifestyle to maintenance of such an in ammatory state has also been shown [15].…”

Section: Introductionmentioning

confidence: 99%

Quantitative Assessment of the Immune Microenvironment in African American Triple Negative Breast Cancer: A Case Control Study

Yaghoobi

Moutafi

et al. 2021

Preprint

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PURPOSETriple Negative Breast Cancer (TNBC) is more common in African American (AA) than Non-AA (NAA) population. We hypothesize that Tumor Microenvironment (TME) contributes to this disparity. Here we use multiplex quantitative immunofluorescence (QIF) to characterize the expression of immunologic biomarkers in the TME in both populations.PATIENTS AND METHODSTNBC tumor resection specimen tissues from a 100-patient case: control cohort including 49 AA and 51 NAA were collected. TME markers including CD45, CD14, CD68, CD206, CD4, CD8, CD20, CD3, Ki67, GzB, Thy1, FAP, aSMA, CD34, Col4, VWF and PD-L1 we quantitatively assessed in every field of view. Mean expression levels were compared between cases and controlsRESULTSAlthough no significant differences were detected in individual lymphoid and myeloid markers, we found that infiltration with CD45+ immune cells (p=0.0102) was higher in TNBC in AA population. AA TNBC tumors also had significantly higher level of lymphocytic infiltration defined as CD45+CD14- cells (p=0.0081). CD3+T-cells in AA tumors expressed significantly higher levels of Ki67 (0.0066) compared to NAAs, indicating that a higher percentage of AA tumors contained activated T-cells. All other biomarkers showed no significant differences between the AA and NAA group.CONCLUSIONSWhile the TME in TNBC is rich in immune cells in both racial groups, there is a numerical increase in lymphoid infiltration in AA compared to NAA TNBC. Significantly higher activated T cells seen in AA patients raises the possibility that there may be a subset of AA patients with improved response to immunotherapy.

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Section: Introductionmentioning

confidence: 99%

Quantitative Assessment of the Immune Microenvironment in African American Triple Negative Breast Cancer: A Case Control Study

Yaghoobi

Moutafi

et al. 2021

Preprint

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Increased perioperative complication rates in patients with solid organ transplants following rotator cuff repair

Kunkle

Reid

Kothandaraman

et al. 2021

Journal of Shoulder and Elbow Surgery

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Quantitative assessment of the immune microenvironment in African American Triple Negative Breast Cancer: a case–control study

et al. 2021

View full text Add to dashboard Cite

Purpose Triple negative breast cancer (TNBC) is more common in African American (AA) than Non-AA (NAA) population. We hypothesize that tumor microenvironment (TME) contributes to this disparity. Here, we use multiplex quantitative immunofluorescence to characterize the expression of immunologic biomarkers in the TME in both populations. Patients and methods TNBC tumor resection specimen tissues from a 100-patient case: control cohort including 49 AA and 51 NAA were collected. TME markers including CD45, CD14, CD68, CD206, CD4, CD8, CD20, CD3, Ki67, GzB, Thy1, FAP, aSMA, CD34, Col4, VWF and PD-L1 we quantitatively assessed in every field of view. Mean expression levels were compared between cases and controls. Results Although no significant differences were detected in individual lymphoid and myeloid markers, we found that infiltration with CD45+ immune cells (p = 0.0102) was higher in TNBC in AA population. AA TNBC tumors also had significantly higher level of lymphocytic infiltration defined as CD45+ CD14− cells (p = 0.0081). CD3+ T-cells in AA tumors expressed significantly higher levels of Ki67 (0.0066) compared to NAAs, indicating that a higher percentage of AA tumors contained activated T-cells. All other biomarkers showed no significant differences between the AA and NAA group. Conclusions While the TME in TNBC is rich in immune cells in both racial groups, there is a numerical increase in lymphoid infiltration in AA compared to NAA TNBC. Significantly, higher activated T cells seen in AA patients raises the possibility that there may be a subset of AA patients with improved response to immunotherapy.

show abstract

CKD in African Americans as a Complex Intertwining of Biology and Socioeconomics: An Introduction

Cited by 3 publications

References 15 publications

Quantitative Assessment of the Immune Microenvironment in African American Triple Negative Breast Cancer: A Case Control Study

Quantitative Assessment of the Immune Microenvironment in African American Triple Negative Breast Cancer: A Case Control Study

Increased perioperative complication rates in patients with solid organ transplants following rotator cuff repair

Quantitative assessment of the immune microenvironment in African American Triple Negative Breast Cancer: a case–control study

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