“…Central line-associated bloodstream infection (CLABSI) rates increased during the coronavirus disease 2019 (COVID-19) pandemic in the United States. 1 , 2 Previous work attributes high volumes of COVID-19 positive inpatients, 3 , 4 , 5 increased central line utilization, 5 , 6 critical illness, 6 decreased volumes of infection prevention practice audits, 7 staffing shortages leading to use of traveling nurses, 8 and supply chain problems 9 as potentially contributing to this increase. At our rural academic medical center, the increase in CLABSI was most notable during the winter of 2021 during the Omicron surge when we cared for the highest number of COVID-19 positive patients.…”