The conservation of contemporary buildings is particularly challenging as only few information about their degradation and guidelines for their maintenance are available and at the same time, despite their architectural importance, the attention and caring procedures are nοt adequate to safeguard standards. The Oslo Opera House is a high-standing contemporary architecture (opening 2008) characterized by a large ornamental pavement cladding mainly made of Apuan marble slabs. After few years, large parts of the marble surface suffered from a marked yellow discoloration and dirt accumulation. In this context, the current research was carried out aiming at assessing the state of conservation of the marble slabs and investigating the causes of their discoloration, to suggest possible remediation and adequate maintenance procedures. Due to the extreme microclimatic conditions, a severe inter-and intra-granular decohesion of the calcite grains can be observed by microscopic analyses, while a surface corrosion phenomenon of the crystals is in progress. The chemical analyses of surface stone material from the slabs allow the detection of deteriorated organic by-products, as a result of the degradation of previous protective treatments, excluding the correlation of iron ions concentration with the discoloration. The state of conservation gathered so far was the starting point for the development of a tailor-made cleaning methodology of the marble cladding and a complete revision of the protective treatments and ordinary maintenance protocol.