Cladophialophora bantiana osteomyelitis in a renal transplant patient

Desmet, Stefaan; Smets, Lena; Lagrou, Katrien; Derdelinckx, Inge; Neyt, J.; Maertens, Johan; Sciot, Raf; Demaerel, Philippe; Bammens, Bert

doi:10.1016/j.mmcr.2016.07.002

Cited by 13 publications

(6 citation statements)

References 17 publications

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“…In fact, the full range of species against which isavuconazole has activity and the clinical breakpoints have not yet been established. Nevertheless, previous studies have demonstrated MIC values of ≤4 μg/mL for many species closely related or identical to the rare pathogens in the current study . Although some isolates in the current study appeared to have reduced susceptibility in vitro compared with those prior studies, we cannot exclude the possibility of cross‐resistance in some patients who failed prior antifungal therapy.…”

Section: Discussioncontrasting

confidence: 74%

Isavuconazole for treatment of rare invasive fungal diseases

Cornely

Mullane

Ostrosky-Zeichner

et al. 2018

Mycoses

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Data regarding treatment of rare invasive fungal diseases (IFDs) are scarce. We documented the efficacy and safety of isavuconazole for treatment of uncommonly diagnosed IFDs. VITAL was a single-arm, international, open-label study evaluating the efficacy and safety of isavuconazole (200 mg orally or intravenously every 8 hours for 48 hours, then once daily). The primary outcome was overall response at Day 42; key secondary outcomes were overall responses at Day 84 and end of treatment (EOT), mortality at Days 42 and 84, and safety. This analysis includes patients with IFD caused by rare or unidentified pathogens. Twenty-six patients with IFDs caused by rare moulds (n = 17), non-Candida yeasts (n = 2), or unidentified moulds (n = 7) were enrolled (median treatment duration [range], 114.5 [1-496]) days. Overall treatment success was observed in 11/26 (42.3%), 10/26 (38.5%), and 15/26 (57.7%) patients at Days 42, 84, and EOT, respectively. All-cause mortality rates were 2/26 patients (7.7%) at Day 42 and 4/26 patients (15.4%) at Day 84; another two patients died after Day 84. All patients had ≥1 treatment-emergent adverse event (TEAE); 15 patients (57.7%) had serious TEAEs, and TEAEs led to discontinuation of isavuconazole in four patients (15.4%). Isavuconazole may be efficacious for treatment of a range of rare IFDs.

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Section: Discussioncontrasting

confidence: 74%

Isavuconazole for treatment of rare invasive fungal diseases

Cornely

Mullane

Ostrosky-Zeichner

et al. 2018

Mycoses

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“…Interestingly, fungal osteomyelitis of the foot due to C. bantiana and Corynespora spp. represent rare fungal infections in this series (26)(27)(28).…”

Section: Discussionmentioning

confidence: 72%

Molecular and Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry-Based Characterization of Clinically Significant Melanized Fungi in India

Singh

Kumar

et al. 2017

J Clin Microbiol

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Melanized or black fungi are a heterogeneous group of fungi causing cutaneous to systemic diseases with high mortality. These fungi are rarely reported as agents of human infections, primarily due to difficulties in their classical identification. In this study, we examined, using molecular methods and matrix-assisted laser desorption ioniazation-time of flight mass spectrometry (MALDI-TOF MS), the diversity of melanized fungi (MF) isolated from patients in 19 medical centers in India. Overall, during a 4-year period, 718 (5.3%) clinical specimens yielded MF. Of these, 72 (10%) isolates had clinical significance and were identified primarily by sequencing the internal transcribed spacer and large subunit (LSU) regions. MF represented 21 genera comprising 29 species, the majority of them belonging to the orders Pleosporales (50%) and Chaetothyriales (22%). Among the 29 fungal species identified in this study, only 6 (20%) species were identified by the MALDI-TOF MS due to the limited commercial database of Bruker Daltonics for MF. However, a 100% identification rate of 20 additional species identified in this study was obtained by constructing an inhouse database using 24-to 96-h-old liquid cultures. Further, the CLSI broth microdilution method revealed low MICs for posaconazole (Յ1 g/ml) and voriconazole (Յ2 g/ml) in 96% and 95% of isolates, respectively. Skin/subcutaneous and sinonasal and pulmonary phaeohyphomycosis due to MF were diagnosed in 21.4% (n ϭ 15) and 28.5% (n ϭ 20) of cases. Also, 10% of patients had central nervous system involvement (n ϭ 7), and 3 cases of fungal osteomyelitis due to Cladophialophora bantiana and Corynespora spp. were observed.

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“…CT imaging of the brain and sinuses excluded concurrent CNS infection. The two other cases initially presented with a non‐CNS site of infection and were found to have CNS abscesses after several days of being hospitalized 24,25 . The authors hypothesized the infection disseminated via hematogenous spread to the brain based on the multiple brain abscesses seen on imaging.…”

Section: Discussionmentioning

confidence: 99%

Cladophialophora bantiana and Nocardia farcinica infection simultaneously occurring in a kidney transplant recipient: Case report and literature review

Cortés

Hata

Libertin

et al. 2021

Immunity Inflam & Disease

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Solid organ transplant recipients are at increased risk of acquiring devastating infections with unusual pathogens. Nocardia are aerobic actinomycetes that affect the lungs, brain, skin and soft tissue. Cladophialophora species are dematiaceous fungi that overwhelmingly cause infections in the brain. Both organisms carry a high mortality rate. We present the first reported renal transplant case with Cladophialophora bantiana involving the renal allograft with concurrent invasive nocardiosis involving the lungs and brain.

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Cladophialophora bantiana osteomyelitis in a renal transplant patient

Cited by 13 publications

References 17 publications

Isavuconazole for treatment of rare invasive fungal diseases

Isavuconazole for treatment of rare invasive fungal diseases

Molecular and Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry-Based Characterization of Clinically Significant Melanized Fungi in India

Cladophialophora bantiana and Nocardia farcinica infection simultaneously occurring in a kidney transplant recipient: Case report and literature review

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