2016
DOI: 10.1016/j.biotechadv.2015.11.005
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Clarification of vaccines: An overview of filter based technology trends and best practices

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Cited by 74 publications
(74 citation statements)
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“…DLS is a non-invasive diagnostic tool for particle sizing and determination of particle size distribution in solutions or colloidal dispersions [50]. From DLS measurements, diffusion coefficient can be obtained from analysis of time-dependent fluctuations of scattered light intensity arising from particles undergoing random Brownian motion [40,51].…”
Section: Validation Of the Dls Methodsmentioning
confidence: 99%
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“…DLS is a non-invasive diagnostic tool for particle sizing and determination of particle size distribution in solutions or colloidal dispersions [50]. From DLS measurements, diffusion coefficient can be obtained from analysis of time-dependent fluctuations of scattered light intensity arising from particles undergoing random Brownian motion [40,51].…”
Section: Validation Of the Dls Methodsmentioning
confidence: 99%
“…Nevertheless, their efficacy in selected low-income countries, where they are needed most, was low during clinical trials and post-licensure studies [19,49]. The reasons for their lower efficacy in developing countries may be due to high levels of maternal antibodies, mixed infections with various pathogens in the gut, a higher rate of malnutrition, regional differences in prevalent RV genotypes and serotypes, and emergence of potentially virulent strains via reassortment of RVs between vaccine strains and circulating wild type strains [19,47,50]. Their attenuated live nature has raised concerns related to viral shading and risk of reversion and transmission [51].…”
Section: The Current Vaccine Paradigmmentioning
confidence: 99%
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