Clarifying the Link Between the Blood Lactate Concentration and Cardiovascular Risk

Abstract

The blood lactate value at rest (Lacrest) is linked to cardiovascular outcomes. It is unclear whether this association holds true in younger, healthy subjects, especially as the pathophysiological connection between Lacrest and cardiometabolic disease is not well understood. The aim of this study is clarifying the link between Lacrest and cardiovascular risk, and to study explanatory factors for the variance of Lacrest concerning metabolism and physical activity in a population of healthy patient-athletes. The distribution and intra-individual variability of Lacrest was assessed based on 9051 samples. The 10-year cardiovascular risk was then approximated using the Framingham risk score in a group of 1315 samples from patient-athletes. Cross-validated linear regression was used to analyze explanatory variables for Lacrest and 10-year cardiovascular risk. Lacrest is weakly associated with the Framingham score. This association disappears when adjusting for blood lipids. Lacrest is also linked to the predominant type of exercise with endurance athletes featuring a higher Lacrest. Lacrest does not independently predict the estimated cardiovascular risk but is associated with lipid parameters. Moreover, the intra-individual variability of Lacrest is high in a relevant number of subjects, which does not point towards the feasibility to use Lacrest as an individual risk factor.

Recent Developments in Protein Lactylation in PTSD and CVD: Novel Strategies and Targets

“…The association of IL-7 with lactylation is significant as, under normal circumstances, this cytokine opposes cellular senescence and lowers blood pressure [ 41 ], suggesting that its dysfunction may drive PTSD and CVD, validating the study of Seligovski et al [ 24 , 39 , 42 , 43 , 44 ]. In this regard, impaired IL-7 signaling with IL-7 receptors (IL-7R) on ECs, likely contributes to PTSD and CVD by promoting early vascular aging (EVA) and premature ECs senescence [ 5 , 34 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ]. In contrast, upregulated HIF-1α exerts cardioprotective and neuroprotective effects and can alleviate many PTSD symptoms [ 50 , 51 , 52 ].…”