Clarithromycin in 2003: sustained efficacy and safety in an era of rising antibiotic resistance

Anzueto, Antonio; Norris, S. H.

doi:10.1016/j.ijantimicag.2004.03.003

Cited by 16 publications

(5 citation statements)

References 134 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These patterns of antimicrobial activity are consistent with other reports that have found CLR to be active in vitro against Gram-positive micro-organisms but a poor inhibitor of Gram-negative micro-organisms (Anzueto & Norris, 2004) and CIP to be active in vitro against Gram-negative microorganisms but less effective against Gram-positive organisms (Dalhoff & Schmitz, 2003). We currently do not have an explanation for the emergence of three Gram-positive infections in animals treated with CLR/14-OH CLR without irradiation.…”

Section: Animals With Irradiationsupporting

confidence: 91%

Comparison of clarithromycin and ciprofloxacin therapy for Bacillus anthracis Sterne infection in mice with or without 60Co gamma-photon irradiation

Brook

Giraldo

Germanà

et al. 2005

Journal of Medical Microbiology

View full text Add to dashboard Cite

Biological agents and ionizing radiation lead to more severe clinical outcomes than either insult alone. This study investigated the survival of non-irradiated and 60 Co-gamma-irradiated mice given therapy for inhalation anthrax with ciprofloxacin (CIP) or a clinically relevant mixture of clarithromycin (CLR) and its major human microbiologically important metabolite 14-hydroxy clarithromycin (14-OH CLR). All B6D2F1/J 10-week-old female mice were inoculated intratracheally with 3 3 10 8 c.f.u. of Bacillus anthracis Sterne spores 4 days after the non-lethal 7 Gy dose of 60 Co gamma radiation. Twenty-one days of treatment with CLR/14-OH CLR, 150 mg kg À1 twice daily, or CIP, 16 . 5 mg kg À1 twice daily, began 24 h after inoculation. Pharmacokinetics indicate that the area under the curve (AUC) for 14-OH CLR on the concentration-versus-time graph was slightly higher in gamma-irradiated than non-irradiated animals. Neither drug was able to increase survival in gammairradiated animals. CIP and CLR/14-OH CLR therapies in non-irradiated animals increased survival from 49 % (17/35 mice) in buffer-treated animals to 94 % (33/35) and 100 %, respectively (P , 0 . 001). B. anthracis Sterne only was isolated from 25-50 % of treated mice with or without irradiation. Mixed infections with B. anthracis Sterne were present in 50-71 % of gamma-irradiated mice but only in 5-10 % of mice without irradiation.

show abstract

Section: Animals With Irradiationsupporting

confidence: 91%

Comparison of clarithromycin and ciprofloxacin therapy for Bacillus anthracis Sterne infection in mice with or without 60Co gamma-photon irradiation

Brook

Giraldo

Germanà

et al. 2005

Journal of Medical Microbiology

View full text Add to dashboard Cite

show abstract

“…It is often linked to tetracycline resistance, as previous studies have reported [11]. This phenotype could be more likely linked to therapeutic failure [12]; however, overall ERY-resistant strains were not appreciably associated with fatal outcomes in this sample; in fact, the opposite was true, although in a non-significant way. The prevalence of macrolide resistance was not significantly different among serotypes, nor was the resistance phenotype.…”

Section: Discussioncontrasting

confidence: 45%

Serotypes and antibiotic susceptibility of Streptococcus pneumoniae isolates causative of invasive diseases in Mexican children

Arredondo-Garcı́a

Calderón

Echániz-Avilés

et al. 2010

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: Streptococcus pneumoniae is a worldwide leading cause of morbidity and mortality, while susceptibility towards penicillin and macrolides can be less than 50% in many regions. Methodology: A total of 150 isolates of S. pneumoniae causative of invasive diseases in children were characterized, of which 24.6% had a fatal outcome. Results: The most prevalent serotypes were 19F, 6B, 23F and 14. Resistance to penicillin, erythromycin (mostly of macrolide-lincosamide-streptogramin resistance phenotype) or trimethoprim-sulfamethoxazole was found in more than 40% of the isolates, but no resistance phenotype appeared linked to lethality. Serotype 3 isolates, which were seldom resistant, had a twofold lethality rate compared to the total sample. Conclusion: Serotyping could provide a better outcome-predicting tool than susceptibility testing. The seven-valent vaccine does not include the most prevalent serotypes found in Mexico.

show abstract

“…Shortly after the discovery of antibiotics, this resulted in a considerable proportion of these drugs becoming inefficient due to what has been later termed "antibiotic resistance" [16][17][18]. Antibiotic resistance (AR) played a major role in the reduction of efficacy of fight against the infectious agents [19][20][21][22]. From a microbiological point of view when exposed Amin Talebi Bezmin Abadi, Albert A. Rizvanov, Thomas Haertlé and Nataliya L. Blatt contributed equally to this work.…”

Section: Introductionmentioning

confidence: 99%

World Health Organization Report: Current Crisis of Antibiotic Resistance

et al. 2019

View full text Add to dashboard Cite

Antibiotic resistance is the most challenging clinical and public health problem. Despite of living in the era of novel technologies in biomedical research, many of untreatable infectious diseases are ranked as the main causes of human death worldwide. Increased antibiotic use in human and use in animal production are the two major causes of emergence of resistant bacteria in hospitals, human communities, and also animal farms. Current body of evidences is indicating that major factors that led to existing crisis on antibiotics worldwide are poor educational programs on hygiene and health, inappropriate prescription in addition to the overprescription in clinical settings (mainly in developing countries with easier access to the antibiotics) and lack of accurate diagnostic tools in laboratories in order to control the emergence of antibiotics against widely used drugs in community. It sounds using the antibodies against problematic bacteria in farms has more benefits than treating them with susceptible antibiotics. As best strategy, we pointed that the crisis of antibiotic resistance may be solved when all contributors be acknowledged to their responsibilities and duties to minimize this global problem threatening the human health. China and the USA as the two main antibiotics user in industrial scale should have taken new policy in meat industry. Currently, antibiotic resistance presents a growing health threat worldwide being the cause of many nosocomial and often deadly infections.

show abstract

Clarithromycin in 2003: sustained efficacy and safety in an era of rising antibiotic resistance

Cited by 16 publications

References 134 publications

Comparison of clarithromycin and ciprofloxacin therapy for Bacillus anthracis Sterne infection in mice with or without 60Co gamma-photon irradiation

Comparison of clarithromycin and ciprofloxacin therapy for Bacillus anthracis Sterne infection in mice with or without 60Co gamma-photon irradiation

Serotypes and antibiotic susceptibility of Streptococcus pneumoniae isolates causative of invasive diseases in Mexican children

World Health Organization Report: Current Crisis of Antibiotic Resistance

Contact Info

Product

Resources

About