Clarithromycin resistance and female gender affect Helicobacter pylori eradication failure in chronic gastritis

Chang, Young Woon; Ko, Weon Jin; Oh, Chi Hyuk; Park, Yoo Min; Oh, Shin Ju; Moon, Ju-Young; Cho, Jun-Hyung; Kim, Jung Wook; Jang, Jun‐Bock

doi:10.3904/kjim.2018.054

Cited by 39 publications

(33 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, there was no signi cant correlation between age and sex of the patients with clarithromycin resistance. This is in line with the results of Korona [41] and Elviss [42] and contrasts with the results of Wang [36], Chang [43], and Treiber [32]. In this study, a signi cant relationship was observed between the degree of chronic in ammation and Glandular Atrophy with antibiotic resistance.…”

Section: Discussionsupporting

confidence: 81%

Correlation Between Clarithromycin Resistance, Virulence Factors and Clinical Characteristics of the Disease in Helicobacter pylori Infected Patients in Shahrekord, Southwest Iran”

Hosseini

Rahimian

Shafigh

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: The purpose of this study was to determine the mutations associatedwith clarithromycin resistance in Helicobacter pylori isolates isolated from biopsy samples that were collected from the endoscopic ward of Shahrekord Hajar teaching Hospital and also to study the frequency of virulence factor and their correlation and pathological findings with clarithromycin resistance during the years 2019-2020. In this cross-sectional descriptive study, 152 patients with Helicobacter pylori infection were considered, and then, two common A2142G and A2143G mutations in the 23SrRNA gene associated with resistance were analyzed by Real-time PCR (Taq man). The presence of vacA, iceA1, iceA2,cagA,babA2, and oipA virulence genes was investigated by PCR and 8% polyacrylamide gel. Then, data were analyzed using the relevant statistical tests.Results: In this study, the frequency of Helicobacter pylori was 76% and the frequency of mutant isolates was 57.2%. The frequencies of A2142G and A2143G point mutations were 42.1% and 28.3%. There was a significant correlation among oipA, vacA, and iceA1 virulence factors, type of disease, chronic inflammatory score, and glandular atrophy with the antibiotic resistance to clarithromycin. There was no significant correlation between the age and sex of the patients with antibiotic resistance.Conclusions: According to the results of this study, It seems that the use of clarithromycin to combat this bacterium should be limited.

show abstract

Section: Discussionsupporting

confidence: 81%

Correlation Between Clarithromycin Resistance, Virulence Factors and Clinical Characteristics of the Disease in Helicobacter pylori Infected Patients in Shahrekord, Southwest Iran”

Hosseini

Rahimian

Shafigh

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…In all studies included, 11 prospective studies compared the H. pylori eradication rate in diabetes and non‐diabetes 29‐39 . Eleven retrospective studies compared the proportion of diabetes and other clinic factors (age, gender, smoking, drinking, overweight, peptic ulcer disease, blood pressure, and history of NSAIDS) in groups failed and succeed in H. pylori eradication 40‐50 . Four studies further compared the level of HbA1c in diabetics failed and succeed in H. pylori eradication 30,35,37,49 .…”

Section: Resultsmentioning

confidence: 99%

“…Twenty‐two studies were included in these part of meta‐analysis, included 11 case‐control studies 29‐39 and 11 cohort studies 40‐50 enrolling in 5466 participants. Among them, three studies were split into two part to be included, 33,36,48 according to their group design.…”

Section: Resultsmentioning

confidence: 99%

The efficacy of Helicobacter pylori eradication in diabetics and its effect on glycemic control: A systematic review and meta‐analysis

et al. 2021

View full text Add to dashboard Cite

Background and Aims Previous studies have revealed the association between Helicobacter pylori (H. pylori) and diabetes mellitus, but conflicts still exist. The present study tried to investigate the underlying link between these two diseases by making comprehensive analyses of the impact of diabetes on H. pylori eradication and the influence of H. pylori eradication on diabetes. Methods We systematically searched relevant studies from PubMed, Cochrane Library, Web of Science, and Embase updated to April 23, 2020. Studies examining the association between H. pylori eradication and diabetes were included. Pooled odds ratio (OR) and weighted mean differences (WMD) were calculated for different results. Results Among the 2125 retrieved studies, 36 studies were included. Patients with type 2 diabetes mellitus (T2DM) have higher risk of H. pylori eradication failure than the non‐diabetic one (OR = 2.59, 95% CI 1.82–3.70). Body mass index (BMI) was identified as a major factor affecting the efficacy of H. pylori eradication in diabetics, and better glycemic control was also found in eradication succeed patients (WMD: 0.51, 95% CI 0.20–0.81). Moreover, after eradication of H. pylori, improvement of HbA1c was proved (WMD = −0.33, 95% CI −0.65 to −0.02) in T2DM. Conclusion A higher risk of H. pylori eradication failure in T2DM was confirmed, and it was associated with BMI and glycemic control. Moreover, we also provided evidence that H. pylori eradication could improve glycemic control in patients with T2DM, which indirectly reflect the interaction between H. pylori and the diabetes.

show abstract

“…35,36 One study showed that female gender (OR, 1.73; 95% CI, 1.15 to 4.25) and clarithromycin resistance (OR, 19.13; 95% CI, 9.35 to 35.09) were strongly associated with eradication failure. 35 Another study also showed that female gender and smoking were associated with the treatment failure. 36 The reason may be also related to clarithromycin resistance and point mutation.…”

Section: Discussionmentioning

confidence: 99%

<p>Eradication Treatment of <em>Helicobacter pylori</em> Infection Based on Molecular Pathologic Antibiotic Resistance</p>

Gao¹,

Du²,

Long³

et al. 2020

IDR

View full text Add to dashboard Cite

Background: Unfortunately, the eradication rate of Helicobacter pylori (H. pylori) treatment is markedly decreasing in recent years and the major reason is antibiotic resistance. Our study was designed to determine the effect and safety of H. pylori eradication treatment based on the molecular pathologic antibiotic resistance. Methods: 261 patients were analyzed retrospectively, including 111 patients who were treated for the first time (one group as First-treated) and 150 patients who failed at least once in bismuth quadruple therapy (another group as Re-treatment). Antibiotic resistance was examined by Real-time PCR detection and conventional PCR and sequencing method. The eradication rate (ER) was compared per intention to treat (ITT) and per protocol (PP) between the two groups. Results: The resistance rates to amoxicillin, clarithromycin, fluoroquinolone and tetracycline were 5.5%, 42.1%, 41.7% and 12.9% in the 111 first-treated patients, and 11.7%, 79.7%, 70.7% and 30.0% in the 150 re-treatment patients. The ERs in the ITT and PP analyses were 92.79% (95% CI, 87.98-97.60%, n=111) and 98.10% (95% CI, 95.48-100%, n=105), respectively, in the first-treated patients and 90.67% (95% CI, 86.01-95.32%, n=150) and 95.10% (95% CI, 91.57-98.64%, n=143), respectively, in the re-treatment patients. No significant differences were shown in the ERs between two group patients, and no serious adverse events were found. Conclusion: H. pylori eradication treatment based on molecular pathologic antibiotic resistance showed good effect and safety in both first and retreated patients.

show abstract

Clarithromycin resistance and female gender affect Helicobacter pylori eradication failure in chronic gastritis

Abstract: Clarithromycin resistance and female gender are factors affecting H. pylori eradication failure in patients with chronic gastritis.

Cited by 39 publications

References 40 publications

Correlation Between Clarithromycin Resistance, Virulence Factors and Clinical Characteristics of the Disease in Helicobacter pylori Infected Patients in Shahrekord, Southwest Iran”

Correlation Between Clarithromycin Resistance, Virulence Factors and Clinical Characteristics of the Disease in Helicobacter pylori Infected Patients in Shahrekord, Southwest Iran”

The efficacy of Helicobacter pylori eradication in diabetics and its effect on glycemic control: A systematic review and meta‐analysis

<p>Eradication Treatment of <em>Helicobacter pylori</em> Infection Based on Molecular Pathologic Antibiotic Resistance</p>

Contact Info

Product

Resources

About