This paper proposes a methodology to monitor the instantaneous value of the current and its derivative in the abc, αβ0, and dq0 reference frames to act in the detection of fault current in medium-voltage distribution systems. The method employed to calculate the derivative was Euler’s, with processing sampling rates of 10, 50, 100, and 200 μs. Using the MATLAB/Simulink platform, fault situations were analyzed on a real feeder of approximately 1.1132 km in length, fed by an 11.4 kV source, composed of 26 unbalanced loads and modeled as constant power. The simulation results show that the detection occurred in the different fault situations implemented in the feeder and that the detection speed is related to the value of the processing sampling rate (PSR) used. Considering all fault situations and regardless of the PSR value used, the total average detection time was 49 µs. Besides that, the joint action of the detection system with the Thyristor Controlled Series Capacitor (TCSC) limited the fault current in each situation. The average detection time for each fault situation analyzed was below the typical time for a recloser to act, regardless of the reference adopted for the analysis.