Introduction: The Mirror Class as an innovative strategy, mediated by communication technologies that reduces costs and that allows exchange between teachers and students from different countries just a click away, is considered a strength to enhance the Internationalization Process in Education Superior.Objective: to document the process to carry out a mirror Pharmacology class between the Domingo Savio Universities of Santa Cruz de la Sierra in Bolivia and San Gregorio de Portoviejo in Ecuador and evaluate the teacher-student perception of this methodology.Methods: The research is exploratory and descriptive with a non-experimental design and a qualitative approach. Theoretical methods (analysis-synthesis and induction-deduction) and empirical methods were used with the application of a questionnaire and the action research method)Results: the acceptance of the students to the Mirror Class is evident, both in the answers to open and closed questions asked.Conclusion: The experience of the Mirror Class between the USGP universities of Ecuador and the UPDS of Bolivia highlights the importance of meticulous prior planning as a fundamental pillar for its success.