Let p be a prime and let Qn,p denote the n-th layer of the cyclotomic Zp-extension of Q. We prove the effective asymptotic FLT over Qn,p for all n ≥ 1 and all primes p ≥ 5 that are non-Wieferich, i.e. 2 p−1 ≡ 1 (mod p 2 ). The effectivity in our result builds on recent work of Thorne proving modularity of elliptic curves over Qn,p.