Class I major histocompatibility proteins are an essential component of the simian virus 40 receptor

Breau, Walter C.; Atwood, Walter J.; Norkin, Leonard C.

doi:10.1128/jvi.66.4.2037-2045.1992

Cited by 102 publications

(29 citation statements)

References 36 publications

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“…is believed to use MHC class I antigens as receptors [11,25]. Early morphological studies showed that class I antigens could be associated with small non-4.2.3.…”

Section: Phagocytosis 421 Clathrin-coated Vesiclesmentioning

confidence: 99%

Mechanisms of enveloped virus entry into animal cells

Klasse

Bron

Marsh

1998

Advanced Drug Delivery Reviews

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The ability of viruses to transfer macromolecules between cells makes them attractive starting points for the design of biological delivery vehicles. Virus-based vectors and sub-viral systems are already finding biotechnological and medical applications for gene, peptide, vaccine and drug delivery. Progress has been made in understanding the cellular and molecular mechanisms underlying virus entry, particularly in identifying virus receptors. However, receptor binding is only a first step and we now have to understand how these molecules facilitate entry, how enveloped viruses fuse with cells or non-enveloped viruses penetrate the cell membrane, and what happens following penetration. Only through these detailed analyses will the full potential of viruses as vectors and delivery vehicles be realised. Here we discuss aspects of the entry mechanisms for several well-characterised viral systems. We do not attempt to provide a fully comprehensive review of virus entry but focus primarily on enveloped viruses.

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“…is believed to use MHC class I antigens as receptors [11,25]. Early morphological studies showed that class I antigens could be associated with small non-4.2.3.…”

Section: Phagocytosis 421 Clathrin-coated Vesiclesmentioning

confidence: 99%

Mechanisms of enveloped virus entry into animal cells

Klasse

Bron

Marsh

1998

Advanced Drug Delivery Reviews

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“…However, as relatively stable membrane domains, it was unclear how caveolae could offer a productive entry pathway for SV40. The related murine polyoma virus has also been reported to internalise via caveolae (Richterová et al 2001;Gilbert et al 2003;Liebl et al 2006), but, while SV40 employs the class I Major Histocompatability Complex as a receptor, murine polyoma virus interacts with sialyloligosaccharide receptors (Breau et al 1992;Stehle and Harrison 1996). Furthermore, murine polyoma virus binding to host cells induces an up-regulation of primary and early response genes that regulate particle internalisation (Zullo et al 1987;Glenn and Eckhart 1990).…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of viral entry: sneaking in the front door

2010

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Recent developments in methods to study virus internalisation are providing clearer insights into mechanisms used by viruses to enter host cells. The use of dominant negative constructs, specific inhibitory drugs and RNAi to selectively prevent entry through particular pathways has provided evidence for the clathrin-mediated entry of hepatitis C virus (HCV) as well as the caveolar entry of Simian Virus 40. Moreover, the ability to image and track fluorescent-labelled virus particles in real-time has begun to challenge the classical plasma membrane entry mechanisms described for poliovirus and human immunodeficiency virus. This review will cover both well-documented entry mechanisms as well as more recent discoveries in the entry pathways of enveloped and non-enveloped viruses. This will include viruses which enter the cytosol directly at the plasma membrane and those which enter via endocytosis and traversal of internal membrane barrier(s). Recent developments in imaging and inhibition of entry pathways have provided insights into the ill-defined entry mechanism of HCV, bringing it to the forefront of viral entry research. Finally, as high-affinity receptors often define viral internalisation pathways, and tropism in vivo, host membrane proteins to which viral particles specifically bind will be discussed throughout.

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“…Many viruses utilize various receptors for attachment and entry into cells. The polyomavirus, simian vacuolating virus 40 (SV 40), binds to the MHC class I molecule at the cell surface [20], but the MHC molecule is not internalized into the cells together with SV 40 [21]. The ganglioside GM1 also binds to SV 40, and is mediated to transport the virus from the plasma membrane to the endoplasmic reticulum (ER), and a role of GM1 as a functional receptor has been suggested [22].…”

Section: Discussionmentioning

confidence: 99%

Establishment of an immunoscreening system using recombinant VP1 protein for the isolation of a monoclonal antibody that blocks JC virus infection

Henmi

Sawa

Iwata

et al. 2005

Biochemical and Biophysical Research Communications

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Polyomavirus JC (JCV) infection causes the fatal human demyelinating disease, progressive multifocal leukoencephalopathy. Although the initial interaction of JCV with host cells occurs through direct binding of the major viral capsid protein (VP1) with cell-surface molecules possessing sialic acid, these molecules have not yet been identified. In order to isolate monoclonal antibodies which inhibit attachment of JCV, we established an immunoscreening system using virus-like particles consisting of the VP1. Using this system, among monoclonal antibodies against the cell membrane fraction from JCV-permissive human neuroblastoma IMR-32 cells, we isolated a monoclonal antibody designated as 24D2 that specifically inhibited attachment and infection of JCV to IMR-32 cells. The antibody 24D2 recognized a single molecule of around 60 kDa in molecular weight in the IMR-32 membrane fraction. Immunohistochemical staining with 24D2 demonstrated immunoreactivity in the cell membrane of JCV-permissive cell lines and glial cells of the human brain. These results suggested that the molecule recognized by 24D2 plays a role in JCV infection, and that it might participate as a receptor or a co-receptor in JCV attachment and entry into the cells.

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Class I major histocompatibility proteins are an essential component of the simian virus 40 receptor

Cited by 102 publications

References 36 publications

Mechanisms of enveloped virus entry into animal cells

Mechanisms of enveloped virus entry into animal cells

Mechanisms of viral entry: sneaking in the front door

Establishment of an immunoscreening system using recombinant VP1 protein for the isolation of a monoclonal antibody that blocks JC virus infection

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