Class-selective voltammetric determination of hydroxycinnamic acids structural analogs using a WS2/catechin-capped AuNPs/carbon black–based nanocomposite sensor

Abstract

A high-performance screen printed-electrode (SPE)-based nanocomposite sensor integrating tungsten disulfide (WS2) flakes decorated with catechin-capped gold nanoparticles (AuNP-CT) and carbon black (CB) is developed. The excellent antifouling properties of WS2 decorated with AuNP-CT into a high conductivity network of CB results in selectivity, sensitivity, and reproducibility in the simultaneous determination of hydroxycinnamic acid (hCN) structural analogs: caffeic (CF), sinapic (SP), and p-coumaric acids (CM). Using Differential Pulse Voltammetry (DPV), the target hCNs resulted in three well-resolved oxidation peaks at SPE-CB-WS2/AuNP-CT sensor. Excellent anti-fouling performance (RSD ip,a ≤ 3%, n =15 for three analytes simultaneous measure) and low detection limits (CF: 0.10 µmol L-1 ; SP: 0.40 µmol L-1 ; CM: 0.40 µmol L-1) are obtained despite the analyzed compounds have a high passivation tendency towards carbon-based sensors. SPE-CB-WS2/AuNP-CT sensor was successfully applied to determine CF, SP, and CM in food samples with good precision (RSD ≤ 4%, n= 3) and recoveries (86-109%; RSD≤ 5%, n= 3). The proposed sensor is the first example exploiting the simultaneous determination of these compounds in food samples. Given its excellent electrochemical performance, low cost, disposability, and ease of use, this SPE-CB-WS2/AuNP-CT nanocomposite sensor represents a powerful candidate for the realization of electrochemical devices for the determination of (bio)compounds with high passivation tendency.

Molecularly Imprinted Polymers Combined with Electrochemical Sensors for Food Contaminants Analysis

“…The growing demand for easy-to-use and inexpensive analytical devices [ 3 , 4 , 5 , 6 ] capable of rapidly providing valuable qualitative and quantitative information increases the interest in electrochemical sensors because of their reduced size, portability, low cost, and low reagent and sample consumption [ 7 ]. A robust electrochemical sensor may require the successful integration of a transducer (an electrochemical cell generally comprising a working electrode, a reference electrode, and a counter electrode) with a biological recognition element (e.g., antibody, protein, enzyme, etc.)…”

Laccase and Tyrosinase Biosensors Used in the Determination of Hydroxycinnamic Acids

“…Their ability to donate electrons, as well as to stabilize phenoxyl radicals depends mainly on the number and position of hydroxyl groups in their structure [ 4 ]. Although the scientific community constantly works to develop easy and rapid methods for the qualitative and quantitative determination of these compounds, the complexity of their chemical structure still causes difficulties in developing detection methods [ 3 , 5 ].…”

Design, Synthesis and Anticancer Evaluation of Substituted Cinnamic Acid Bearing 2-Quinolone Hybrid Derivatives

“…The hydroxy cinnamic acids are natural products arisen from the deamination of the phenyl alanine. Natural hydroxy cinnamates are extremely potent antitumor agents [ 20 , 21 , 22 ]. Chemically, it is an aromatic fatty acid composed of a phenyl ring substituted with an acrylic acid group, commonly in the trans-geometry, and has low toxicity in human exposure.…”