Class-specific antibody in human dermatophytosis reactive withTrichophyton rubrum derived antigen

Hamouda, T; Jeffries, C. D.; Ekladios, E. M.; El-Mishad, Abla M.; El-Koomy, Medhat; Saleh, Nadia

doi:10.1007/bf01103063

Mycopathologia

1994

DOI: 10.1007/bf01103063

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Class-specific antibody in human dermatophytosis reactive withTrichophyton rubrum derived antigen

T Hamouda

C. D. Jeffries

E. M. Ekladios

et al.

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Cited by 5 publications

(1 citation statement)

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“…In addition, antibodies are generated that do not confer protection or even enhance disease (13,14,40). Antibody isotypes and their role in the humoral immune response of patients have been studied in several types of mycosis (5,11,20,24,46,50). For instance, in paracoccidioidomycosis, there is a differential expression of isotypes to the major Paracoccidioides brasiliensis antigen, a 43-kDa glycoprotein.…”

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confidence: 99%

Immunoglobulins G, M, and A againstSporothrix schenckiiExoantigens in Patients with Sporotrichosis before and during Treatment with Itraconazole

Almeida‐Paes

Pimenta

Monteiro

et al. 2007

Clin Vaccine Immunol

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Sporotrichosis is an important subcutaneous mycosis, with an increasing worldwide incidence. However, few data are available regarding the immunological aspects of Sporothrix schenckii infection, particularly the humoral responses to the fungus. In this study we measured immunoglobulin G (IgG), IgM, and IgA in sera from 41 patients with sporotrichosis before antifungal treatment and from another 35 patients with sporotrichosis during itraconazole treatment by using a recently described S. schenckii exoantigen enzyme-linked immunosorbent assay (ELISA). More than 95% of patients had detectable IgA antibodies, and more than 85% had IgM and IgG antibodies before treatment. The number of patients with IgG antibodies increased to 91% during treatment. Conversely, significantly fewer samples from treated patients were positive for IgM (71%) and IgA (89%). Overall, 78% of patients had detectable levels of all isotypes tested at diagnosis, and this percentage dropped to 62.9% in patients receiving itraconazole. Testing of all three isotypes improved the sensitivity; at least two isotypes were detected in 93% of patients before and 89% after treatment. The reactivity of 94 sera from patients with other diseases and healthy individuals was also tested. Cross-reactivity occurred in 33% of the heterologous sera. Most of them were positive only in one isotype, 8.5% were positive for at least two isotypes, and only one serum (1.1%) was positive for the three isotypes. Antibodies produced during S. schenckii infection are diverse, and we demonstrate that an exoantigen ELISA for the detection of combinations of IgA, IgG, and IgM antibodies is a highly sensitive and specific diagnostic assay for sporotrichosis.

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confidence: 99%

Immunoglobulins G, M, and A againstSporothrix schenckiiExoantigens in Patients with Sporotrichosis before and during Treatment with Itraconazole

Almeida‐Paes

Pimenta

Monteiro

et al. 2007

Clin Vaccine Immunol

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Dermatophyte–host relationship of a murine model of experimental invasive dermatophytosis

Venturini

Álvares

Camargo

et al. 2012

Microbes and Infection

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One stop mycology

Frazer

Moore

1995

Mycological Research

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Class-specific antibody in human dermatophytosis reactive withTrichophyton rubrum derived antigen

Cited by 5 publications

References 18 publications

Immunoglobulins G, M, and A againstSporothrix schenckiiExoantigens in Patients with Sporotrichosis before and during Treatment with Itraconazole

Immunoglobulins G, M, and A againstSporothrix schenckiiExoantigens in Patients with Sporotrichosis before and during Treatment with Itraconazole

Dermatophyte–host relationship of a murine model of experimental invasive dermatophytosis

One stop mycology

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