Classic and Modern Approaches to Investigating Interactions Between Dopamine Systems and Metabotropic Glutamate Receptors

Johnson, Kari A.

doi:10.1007/978-1-0716-1107-4_7

Cited by 2 publications

(1 citation statement)

References 211 publications

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“…mGlu 2 receptors are primarily expressed at presynaptic sites of glutamatergic synapses, where they reduce neurotransmitter release by inhibiting voltage-gated calcium channels (Kupferschmidt & Lovinger, 2015;Niswender & Conn, 2010). Activation of mGlu 2 reduces dopamine release in the dorsal striatum and NAc (reviewed in Johnson, 2021). However, mGlu 2 expression is not detected in midbrain dopamine neurons, and mGlu 2 agonists do not reduce dopamine release or associated behavioral effects produced by direct stimulation of midbrain dopamine neurons (Pehrson & Moghaddam, 2010); these findings indicate that mGlu 2 modulates dopamine release indirectly.…”

Section: Modulation Of Dopamine Transmission By Metabotropic Glutamat...mentioning

confidence: 99%

G protein-coupled receptor modulation of striatal dopamine transmission: Implications for substance use disorders

Littlepage-Saunders

Hochstein

Chang

et al. 2023

Preprint

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Dopamine transmission in the striatum is a critical mediator of the rewarding and reinforcing effects of commonly misused psychoactive drugs. G protein-coupled receptors (GPCRs) that bind a variety of neuromodulators including dopamine, endocannabinoids, acetylcholine, and endogenous opioid peptides regulate dopamine release by acting on several components of dopaminergic circuitry. Striatal dopamine release can be driven by both somatic action potential firing and local mechanisms that depend on acetylcholine released from striatal cholinergic interneurons. GPCRs that primarily regulate somatic firing of dopamine neurons via direct effects or modulation of synaptic inputs are likely to impact distinct aspects of behavior and psychoactive drug actions compared with GPCRs that primarily regulate local acetylcholine-dependent dopamine release in striatal regions. This review will highlight mechanisms by which GPCRs modulate dopaminergic transmission and the relevance of these findings to psychoactive drugs involved in substance use disorders.

show abstract

Section: Modulation Of Dopamine Transmission By Metabotropic Glutamat...mentioning

confidence: 99%

G protein-coupled receptor modulation of striatal dopamine transmission: Implications for substance use disorders

Littlepage-Saunders

Hochstein

Chang

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

G protein‐coupled receptor modulation of striatal dopamine transmission: Implications for psychoactive drug effects

Littlepage-Saunders

Hochstein

Chang

et al. 2023

British J Pharmacology

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Dopamine transmission in the striatum is a critical mediator of the rewarding and reinforcing effects of commonly misused psychoactive drugs. G protein‐coupled receptors (GPCRs) that bind a variety of neuromodulators including dopamine, endocannabinoids, acetylcholine and endogenous opioid peptides regulate dopamine release by acting on several components of dopaminergic circuitry. Striatal dopamine release can be driven by both somatic action potential firing and local mechanisms that depend on acetylcholine released from striatal cholinergic interneurons. GPCRs that primarily regulate somatic firing of dopamine neurons via direct effects or modulation of synaptic inputs are likely to affect distinct aspects of behaviour and psychoactive drug actions compared with those GPCRs that primarily regulate local acetylcholine‐dependent dopamine release in striatal regions. This review will highlight mechanisms by which GPCRs modulate dopaminergic transmission and the relevance of these findings to psychoactive drug effects on physiology and behaviour.

show abstract

Classic and Modern Approaches to Investigating Interactions Between Dopamine Systems and Metabotropic Glutamate Receptors

Cited by 2 publications

References 211 publications

G protein-coupled receptor modulation of striatal dopamine transmission: Implications for substance use disorders

G protein-coupled receptor modulation of striatal dopamine transmission: Implications for substance use disorders

G protein‐coupled receptor modulation of striatal dopamine transmission: Implications for psychoactive drug effects

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