Classic follicular dendritic reticulum cell tumor of the lymph node developing in a patient with a previous inflammatory pseudotumor–like proliferation

Cossu, Antonio; Lissia, Amelia; Dedola, Maria Filomena; Deiana, Angelo; Faedda, Rossana; Palmieri, Giuseppe; Tanda, Francesco

doi:10.1016/j.humpath.2004.12.004

Cited by 12 publications

(8 citation statements)

References 13 publications

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“…Although only one splenic case showed a component that was indistinguishable morphologically from a conventional FDC tumor, the authors believed that such FDC proliferations were neoplastic. Cossu et al [15] in 2005 reported a classic FDC tumor developing in a 31-year-old woman, at a site where a nodal IPT-like proliferation was removed 6 years earlier. It is of great interest that in the initial IPTlike lesion, groups of irregularly and loosely arranged CD21-positive cells were noted.…”

Section: Discussionmentioning

confidence: 99%

“…All these observations suggest that either FDC sarcoma can present at a very early stage as an IPT-like condition or a subset of IPT has the potential to evolve into an FDC sarcoma. Of interest also is the fact that all hepatic cases [39,41,42] (including that reported by Cheuk et al [12]) exhibited EBV genome in the tumor cells whereas the nodal FDC sarcoma that developed at the site of a previously excised IPT did not [15].…”

Section: Discussionmentioning

confidence: 99%

“…All these cases seem to share a heavy inflammatory infiltrate that may contain plasma cells. Most nonhepatic FDC sarcomas, on the other hand, may have an inciting factor not related to EBV [15]. Some such cases might also undergo an IPT-like proliferation at an early stage or might have evolved from an IPT-like condition.…”

Section: Discussionmentioning

confidence: 99%

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Extranodal follicular dendritic cell sarcoma: clinical, pathologic, and histogenetic characteristics of an underrecognized disease entity

et al. 2006

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It has been more than 10 years since follicular dendritic cell (FDC) sarcoma was first reported to occur in extranodal sites, yet extranodal FDC sarcoma still appears underrecognized, and its clinical and pathological characteristics remain to be defined. This study analyzed the clinical and pathological findings of three such cases that the authors encountered recently and 43 previously reported cases identified in the literature. Assessment of all 46 cases showed a slight female predominance (1.2:1) with a median age of 41.5 years. One-third of the cases were misdiagnosed at initial evaluation mainly because the possibility of FDC sarcoma was not considered. When considered, this disease had distinct pathological characteristics that allowed an accurate diagnosis. Staining for FDC markers, CD21, CD35, and clusterin was particularly helpful. The pathogenesis of the disease appeared heterogeneous, and associated factors included Epstein-Barr virus infection (in hepatic cases) and inflammatory pseudotumor-like conditions. Treatment modality varied widely although surgical resection was often included. With a median follow-up of 18 months, 43% of the cases recurred and 7% died of disease. The 5-year recurrence-free survival was 27.4%. From data available at the current time, we were not able to identify prognostically significant pathologic factors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Extranodal follicular dendritic cell sarcoma: clinical, pathologic, and histogenetic characteristics of an underrecognized disease entity

et al. 2006

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“…Darüber hinaus finden sich in > 60% der Fälle eine Positivität für ALK [15] sowie in Abgrenzung zum anaplastisch-großzelligen Lymphom und zum "inflammatorischen pseudotumorartigen follikulär-dendritischen Zelltumor" ("IPT-like FDC") eine Negativität für CD30, CD21 und CD35. Letzterer ist differentialdiagnostisch wichtig, da er nicht nur histopathologisch, sondern auch klinisch (Paraneoplasie) einen IMT imitieren kann, jedoch in fast allen Fällen mit EBV assoziiert ist [8]. Darüber hinaus kommen differentialdiagnostisch u.a.…”

Section: Therapie Und Verlaufunclassified

Inflammatory Myofibroblastic Tumor of the Lymph Node with Paraneoplastic Thrombosis and Eosinophilia

et al. 2010

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The IMT is a rare soft-tissue tumor of intermediate dignity with a low tendency to metastasize. It is consistently accompanied by paraneoplastic syndromes. Therapy of choice is complete resection of the tumor. In nonresectable cases, corticosteroids and nonsteroidal antirheumatics have been shown to be effective. Because of the variable clinical course ranging from spontaneous regression to metastasis, IMTs might be separated into different entities (autoimmune, inflammatory, neoplastic subtype) which thus far cannot be classified on a histopathologic basis. A clinical assessment of the dignity is therefore important until further subclassifications of this rare disease become available.

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“…It is a tumor of young adults usually presenting less than 50 years of age with no gender predilection. There is an association with hyaline-vascular Castleman follicular hyperplasia [4] and Epstein-Barr virus in cases associated with inflammatory pseudo-tumor [5,6]. Both recurrence and metastasis can occur.…”

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confidence: 99%

A rare sarcoma diagnosed on fine needle aspiration in two patients with Castleman disease: Clinical cases with questions for students

Yu¹,

Kundu²

2014

Med podmladak

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C a se 1 :A 38 ye ar old fem ale pr ese nte d wi th a 3.6 x 1.8 cm pe ri-ao rti c ma ss an d ret rop eriton ea l lym ph ad en op ath y. Sh e ini tia lly pr ese nte d at an ou tsi de ins titu tio n wi th a lar ge rig ht su pr are na l ma ss sev en ye ars pr ior wh ich wa s dia gn os ed on co re ne ed le bio ps y as hy ali ne va scu lar Ca stl em an dis eas e. Aft er rec eiv ing ch em oth era py of ge mc ita bin e an d Ta xo ter e pa rti al rem iss ion wa s ach iev ed . Sh e su bs eq ue ntl y un de rw en t su rgi ca l ex cis ion of the rig ht su pr arena l ma ss an d rig ht kid ne y at M D An de rso n Ca nc er Ce nte r. Th e res ect ed sp eci me n sh ow ed lar ge sp ind le an d ep ith eli oid tum or cel ls in a ba ck gro un d of sm all ma tur e lym ph oc yte s. M an y tum or cel ls ha d pr om ine nt nu cle ar ps eu do inc lus ion s. Th ere we re als o are as wi th pr om ine nt pr oli fer ati on of pla sm a cel ls, wi th de po sit ion of am or ph ou s eo sin op hil ic ex tra cel lul ar ma teria l. Ad dit ion all y, foc al dy str op hic ca lci fic ati on wa s pr ese nt. In sit u hy br idi zat ion for ka pp a an d lam bd a im mu no glo bu lin lig ht-ch ain sh ow ed a po lyt yp ic pa tte rn of po sit ivi ty in pla sm a cel ls for ka pp a an d lam bd a lig ht ch ain s. Th e sp ind led an d ep ith eli oid tum or cel ls we re po sitiv e for CD 21 , CD 35 , clu ste rin an d vim en tin by im mu no his toc he mi str y. Th e im ag es fro m the asp ira te sm ear s an d cel l blo ck are sh ow n be low (im ag e 1-3 ). Image 1. Pap stained smear, 20x (A), 40x (B) and 60x (C) magnification.

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Classic follicular dendritic reticulum cell tumor of the lymph node developing in a patient with a previous inflammatory pseudotumor–like proliferation

Cited by 12 publications

References 13 publications

Extranodal follicular dendritic cell sarcoma: clinical, pathologic, and histogenetic characteristics of an underrecognized disease entity

Extranodal follicular dendritic cell sarcoma: clinical, pathologic, and histogenetic characteristics of an underrecognized disease entity

Inflammatory Myofibroblastic Tumor of the Lymph Node with Paraneoplastic Thrombosis and Eosinophilia

A rare sarcoma diagnosed on fine needle aspiration in two patients with Castleman disease: Clinical cases with questions for students

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