Classic Galactosemia Neurological Complications: An Overview

Abstract

Classic galactosemia is an autosomic recessive disorder that leads to increasegalactose 1 phosphate and galactitol intracellular levels; with clinical manifestations that arise from the ingestion of galactose from the diet but can be reverted when restricted. Yet about 90% of the patients develop neurological complications. Because of that we evaluate the impact of the diet on the generation of such complications, like the strict galactose restriction and the glycosilation impairment, galactosemia and social interactions as factors that influence neurodevelopment, oxidative stress secondary to galactosemia and its influence on neuroinflamation, epigenetics modifications secondary to the diet and the social interactions and other causes that can affect neurodevelopment on galactosemia.