Classic IgG4‐related sclerosing mastitis is not so
            <i>classic</i>

Erivwo, Polycarp; Bharatwal, Veera; Huang, Madeline; Godra, Anita; Turashvili, Gulisa

doi:10.1111/tbj.13846

Cited by 9 publications

(3 citation statements)

References 17 publications

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“…In other words, estrogen may play a role in some patients with IgG4-RM. In previous reports, IgG4-RM was mostly found in middle-aged women, and its location was no different between left and right, indicating a favorable prognosis [ 3 , 7 ].…”

Section: Discussionmentioning

confidence: 98%

“…IgG-RD is frequently observed in the pancreas, lacrimal gland and salivary gland, whereas reports of IgG-RD affecting the mammary gland are rare [ 3 , 7 ]. The current hypothesis of IgG4-RD immune disorders is a B-cell-mediated immunologic response to an unknown antigen, with follicular T-helper cells modulating a class switch toward IgG4 [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…Although IgG4-RD may exhibit characteristics of a systemic disease, it often remains restricted to a single organ [ 2 ]. IgG4-RD has an unknown etiology, and although it can occur in various organs, it is rarely observed in mammary glands [ 3 ]. Here, we report a case of IgG4-related mastitis (IgG4-RM) that needed to be differentiated from breast cancer.…”

Section: Introductionmentioning

confidence: 99%

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IgG4-related mastitis requiring differentiation from breast cancer: a case report

Asano

Kashiwagi

Kawano

et al. 2021

Journal of Surgical Case Reports

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Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a group of chronic relapsing inflammatory conditions. Although IgG4-RD can occur in various organs, it is rarely observed in mammary glands. Here, we report a case of IgG4-related mastitis (IgG4-RM) that needed to be differentiated from breast cancer. A 54-year-old woman was examined for a tumor in her left breast. Mammary ultrasonography revealed an irregular hypoechoic tumor measuring 45.0 × 43.0 × 32.0 mm in size. A core-needle biopsy of the left breast tissue revealed a high degree of mixed T and B lymphocytic and plasma cell infiltration, as well as interstitial fibrosis. IgG4-RD was diagnosed based on hematological examination that revealed an abnormal IgG4 value of 332 mg/dl. All the clinical diagnostic criteria for IgG4 were met, resulting in a definitive diagnosis of IgG4-RM.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

IgG4-related mastitis requiring differentiation from breast cancer: a case report

Asano

Kashiwagi

Kawano

et al. 2021

Journal of Surgical Case Reports

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Inflammatory, Reactive, and Infectious Conditions of the Breast

Grabenstetter

D’Alfonso

2022

A Comprehensive Guide to Core Needle Biopsies of the Breast

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Pathology of IgG4-related sclerosing mastitis

Erivwo

Turashvili

2020

J Clin Pathol

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Immunoglobulin G4-related sclerosing mastitis (IgG4-RM) is a recently recognised member of the IgG4-related disease (IgG4-RD) family, a multisystem fibroinflammatory condition that can affect any organ system. IgG4-RM is rare and predominantly occurs in middle-aged women. It may present with painless palpable mass and/or lymphadenopathy thereby mimicking breast cancer. Although there is an abundance of literature describing the clinicopathological characteristics of IgG4-RD in a variety of organs, data on IgG4-RM are limited due to its rarity. This review describes the manifestation of the disease in the breast based on reported cases, emphasising the clinicopathological features, pathophysiology, differential diagnosis, treatment and prognosis.

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Classic IgG4‐related sclerosing mastitis is not so classic

Cited by 9 publications

References 17 publications

IgG4-related mastitis requiring differentiation from breast cancer: a case report

IgG4-related mastitis requiring differentiation from breast cancer: a case report

Inflammatory, Reactive, and Infectious Conditions of the Breast

Pathology of IgG4-related sclerosing mastitis

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