Classic Kaposi's sarcoma as a second primary neoplasm

Cause-specific mortality in classic Kaposi's sarcoma: a population-based study in Italy (1995–2002)

“…Regarding lymphoid malignancies, the 11-fold excess for CLL confirms the significantly increased risk of KS among persons with CLL (Iscovich et al, 1999b;Hisada et al, 2001). The four-fold excess for NHL is also consistent with previous studies (Iscovich et al, 1999a, b;Cannon et al, 2000).…”

“…Several studies have found an association (either positive or negative) between CKS and an additional primary cancer, both when CKS was the first primary neoplasm (Franceschi et al, 1996;Hjalgrim et al, 1997;Iscovich et al, 1999a) and when it was the second primary neoplasm (Iscovich et al, 1999b;Hisada et al, 2001), or regardless of the temporal order of diagnosis (Cannon et al, 2000). A few studies have also reported an association (positive or negative) with a variety of non-neoplastic diseases (Goedert et al, 2002;Guttman-Yassky et al, 2006;Anderson et al, 2008).…”

Classic Kaposi Sarcoma in the United States over the last two decades: A clinicopathologic and molecular study of 438 non-HIV-related Kaposi Sarcoma patients with comparison to HIV-related Kaposi Sarcoma

“…4 While a controversial increased incidence of multiple myeloma and other hematopoietic neoplasms in Classic Kaposi Sarcoma has been extensively reported in the literature, 14,16,18,[21][22][23][24][25][26][27][28][29] the suggested link between HHV-8 and multiple myeloma 30 supports an increase, such as noted in our study, in multiple myeloma in Kaposi Sarcoma patients. An increased incidence of other hematopoietic neoplasms was also observed in our cohort.…”

“…9 Furthermore, despite the occurrence of HHV-8 in prostate specimens of healthy males and in the genitourinary tract of normal females, there was a decreased incidence in prostate carcinoma and female genital tract malignancies in these Classic Kaposi Sarcoma patients, comparable with previous reports. 10,19,23 The reported increased risk of developing Classic Kaposi Sarcoma after breast carcinoma 23 could not be substantiated in this study as only one patient had a history of breast carcinoma. This is likely a reflection of the previously noted lack of available slides and history from many of the females in our database.…”

“…1,15-17,20-22 Iscovich et al 23 report Classic Kaposi Sarcoma as a primary neoplasm in 16.6% of patients 9 and as a second primary neoplasm in 8.3%. Although, Classic Kaposi Sarcoma is reportedly more commonly a primary than a secondary neoplasm, 9,23 a temporal relationship was not investigated in this cohort.…”