Classic Kaposi's sarcoma in Greece: a clinico‐epidemiological profile

Abstract

CKS in Greece exhibits some special characteristics, including older age of onset; lower male to female ratio; endemic clustering; disseminated skin disease at diagnosis, often accompanied by lymphedema; not unusual visceral or lymph node involvement and association with second malignancies. We suggest that CKS in Greece possibly represents a distinct endemic subtype of CKS.

Classic Kaposi Sarcoma in the United States over the last two decades: A clinicopathologic and molecular study of 438 non-HIV-related Kaposi Sarcoma patients with comparison to HIV-related Kaposi Sarcoma

“…[14][15][16][17] While Classic Kaposi Sarcoma lesions in this cohort were generally manifest in the lower extremities, followed by the upper extremities and head and neck, our study reveals less upper extremity, lymph node, and visceral sites than previously reported for Classic Kaposi Sarcoma. 1,9,15,17,18 The findings of a large number (n ¼ 15) of Classic Kaposi Sarcoma in the penis in the current study may relate to the previous identification of HHV-8 in semen, even in normal individuals. 19 In comparison, the AIDS-related Kaposi Sarcoma had fewer lower extremity lesions and included more sites highly predictive of HIV infection: that is oral and anogenital.…”

Classic Kaposi’s sarcoma: The clinical, demographic and teratment characteristics of seventy-four patients

“…Bu, kadın hastalarımızın büyük kısmının postmenopozal evrede olması ile açıklanabilir. Yunanistan'da yapılan çalışmada da bizim çalışmamızla benzer şekilde erkek/kadın oranı daha düşük olarak izlenmiştir 17 . Bu, coğrafyamızda hastalığın ayrı bir endemik varyantı ile ilişkili olabileceği gibi hastalığın çevresel faktörlerin etkisiyle klinik seyrinde zamanla oluşabilecek farklılıklar ile de bağlantılı olabilir.…”

“…Çeşitli yayınlarda KS'ye özellikle lenfoproliferatif hastalıklar daha sık olmak üzere diğer primer malignitelerin eşlik edebileceği bildirilmiştir 11 . KKS ile sıklıkla ilşkili olan tümörler arasında Hodgkin veya non-Hodgkin lenfoma, kronik lenfositik lösemi, multipl miyeloma, mikozis fungoides, tüylü hücreli lösemi bulunmaktadır 17 . Bizim çalışmamızda bir hastada prostat kanseri ve bir hastada kolon kanseri bulunmaktaydı.…”

Bone Involvement in a Case of Kaposi Sarcoma

“…Bone involvement has been reported in some cases of classical KS [2, 3, 4, 5, 6]. The frequency of bone involvement appears to be variable since no case was reported in the series of 67 classical KS of Friedman-Birnbaum et al [1], while 3 cases were reported in the series of 66 cases of Stratigos et al [5].…”

“…Extracutaneous lesions are rare in classical KS [1]and bone involvement has rarely been reported [2, 3, 4, 5, 6]. However, bone involvement seems to be more frequent in African KS [7]and AIDS-related KS [8, 9, 10, 11, 12, 13, 14].…”