Classic pars planitis: strong correlation of class II genes with gender and some clinical features in Mexican mestizos

Aláez, C.; Arellanes, Lourdes; Vázquez, Alfredo Macías; Flores, H.; Navarro, Patricia; Vázquez-García, M.N.; Gorodezky, Clara

doi:10.1016/s0198-8859(03)00185-x

Cited by 15 publications

(9 citation statements)

References 41 publications

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“…A cohort of Mestizo pars planitis patients revealed an association with DRB1*0802. 26 Furthermore, a recent study examining HLA in patients with bilateral anterior uveitis manifestations similar to those seen in tubulointerstitial nephritis and uveitis (TINU) syndrome, but who have not developed renal inflammation, detected an association of uveitis with DRB1*08. 27 …”

Section: Other Classical Hla Genesmentioning

confidence: 99%

An Update on the Genetics of HLA B27-associated Acute Anterior Uveitis

Martin

Rosenbaum

2011

Ocular Immunology and Inflammation

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The discovery of the association of HLA B27 with spondyloarthropathy led to more questions than answers about the role of this gene in disease susceptibility. The realization that HLA B27 was not responsible for all of the genetic effect helped to lay a foundation for further investigation into the genetics of uveitis. Over several decades, genetic findings have provided clues to advance the understanding of mechanisms of uveitis and to catalyze new research on diagnostics, animal models and therapies. From the early candidate gene studies on immune mediators to the recent genome-wide investigations, much has been discovered. However, these discoveries have come with the caveat that a genetic finding does not automatically reveal the disease-relevant functional effect of the associated variant.

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Section: Other Classical Hla Genesmentioning

confidence: 99%

An Update on the Genetics of HLA B27-associated Acute Anterior Uveitis

Martin

Rosenbaum

2011

Ocular Immunology and Inflammation

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“…It is worth mentioning that a differential gender association has been previously described in other autoimmune disease [42,43,44] and also in VKH patients from Singapore, where male gender was clinically associated with a higher risk of chorioretinal degeneration and vitiligo [45]. The role of DR4 alleles in the pathogenesis of VKH seem to be gender biased, as shown in RA [44], in which the penetrance of the shared-epitope genotype and onset are gender related, with the disease being most penetrant in women with *04:01 genotypes [46] and the onset of arthritis being earlier in females [47].…”

Section: Discussionmentioning

confidence: 67%

Major histocompatibility complex and strong human leukocyte antigen–DRB1 and gender association with Vogt–Koyanagi–Harada syndrome in Mexican Mestizos

et al. 2011

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“…In addition to the HLA-B27 MHC class I gene, an MHC class II gene, HLA-DR13, has been implicated in the genetic predisposition to spondyloarthritis in a French cohort. 9 The latter study found the DRB1*0802/DQA1*0401/DQB1*0402 haplotype to be significantly increased in patients with classic pars planitis. [5][6][7] This association is actually due to HLA-DR15, 1 of the 2 suballeles of HLA-DR2.…”

Section: N Introductionmentioning

confidence: 86%