Classical fever of unknown origin in 21 countries with different economic development: an international ID-IRI study

Erdem, Hakan; Baymakova, Magdalena; Alkan, Sevil; Létaief, A.; Yahia, W. Ben; Dayyab, Farouq; Kolovani, Entela; Cosentino, Federica; Hasanoğlu, İmran; Khedr, Reham; Marino, Andrea; Pekok, Abdullah Umut; Eser, Fatma; Arapović, Jurica; Güner, Rahmet; Miftode, Ionela-Larisa; Poposki, Kostadin; Şanlıdağ, Gamze; Tahmaz, Alper; Sıpahi, Oğuz Reşat; Miftode, Egidia; Öncü, Serkan; Cagla-Sonmezer, Meliha; Addepalli, Syam Kumar; Darazam, Ilad Alavi; Kumari, Hema Prakash; Koç, Meliha Meriç; Kumar, Meela Ranjith; Sayana, Suresh Babu; Wegdan, Ahmed Ashraf; Amer, Fatma; Ceylan, Mehmet Reşat; El-Kholy, Amani; ÖNDER, Taylan; Tehrani, Hamed Azhdari; Hakamifard, Atousa; Kayaaslan, Bircan; Shehata, Ghaydaa A.; Çaşkurlu, Hülya; El-Sayed, Nagwa Mostafa; Mortazavi, Seyed Erfan; Pourali, Mohammad; Elbahr, Umran; Kulzhanova, Sholpan; Yetişyiğit, Tarkan; Saad, Sahar; Çağ, Yasemin; Eser-Karlidag, Gulden; Pshenichnaya, N.; Belitova, M.; Akhtar, Nasim; Almajid, Fahad; Ayhan, Müge; Khan, Mumtaz Ali; Lanzafame, Massimiliano; Makek, Mateja Janković; Nsutebu, Emmanuel; Dindar-Demiray, Emine Kubra; Evren, Emine Ünal; Kalas, Rama; Kalem, Ayşe Kaya; Baljić, Rusmir; Ikram, Aamer; Kaya, Selçuk; Líšková, Anna; Szabó, Bálint Gergely; Rahimi, Bilal Ahmad; Mutlu-Yilmaz, Esmeray; Şener, Alper; Rello, Jordi

doi:10.1007/s10096-023-04561-5

Cited by 8 publications

(10 citation statements)

References 27 publications

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“…Miscellaneous causes of FUO include cirrhosis, drug fever, thyroiditis, pulmonary emboli, Crohn's disease, and familial periodic fever syndrome, to name a few [40]. A recently published article indicated that miscellaneous causes comprise 2-14% of all causes of FUO and showed that thyroiditis, histiocytosis, Crohn's disease, and macrophage activation syndrome are the most common miscellaneous causes of FUO [5]. There are limited studies related to the application of [ 18 F]FDG PET/CT for detecting miscellaneous causes of FUO.…”

Section: F]fdg Pet/ct In Other Causes Of Fuomentioning

confidence: 99%

“…The underlying etiologies of FUO can be grouped into five categories: infection, neoplasia, inflammation, miscellaneous, and idiopathic illness; infection remains a major contributor [3]. The etiologies of FUO depend in large part on the type of population, their socioeconomic status, and the healthcare facilities available in their area [4,5]. Based on data from a study published recently in 2023, which included 788 subjects from 21 countries with different economic developments, the causes of FUO were infection in 51.6%, neoplasm in 11.4%, collagen vascular disease in 9.3%, miscellaneous in 7.7%, and 20.1% of cases were undiagnosed [5].…”

Section: Introductionmentioning

confidence: 99%

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[18F]FDG PET/CT for identifying the causes of fever of unknown origin (FUO)

Singh

2024

Am J Nucl Med Mol Imaging

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Fever of unknown origin (FUO) continues to be a challenging diagnosis in clinical medicine. It has more than 200 known causes, including infections, autoimmune diseases, neoplasia, and other miscellaneous disorders. Despite the development of a wide range of diagnostic tools, a specific diagnostic algorithm for FUO is not yet available. However, [ 18 F]FDG PET/CT, which yields information on cellular metabolism, in addition to details of organ anatomy, has been shown to be successful in the FUO investigation. This study highlights the uses of [ 18 F]FDG PET/CT in diagnosing various causes of FUO. [ 18 F]FDG PET/CT has been increasingly used to detect septic infections, sterile inflammatory processes, and malignancies, occupying a significant portion of the known causes of FUO. It has led to a more definitive identification of the etiology of FUO and accurate clinical management. However, more in-depth studies are crucial to understanding if [ 18 F]FDG PET/CT can be used in the work-up of FUO.

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Section: F]fdg Pet/ct In Other Causes Of Fuomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

[18F]FDG PET/CT for identifying the causes of fever of unknown origin (FUO)

Singh

2024

Am J Nucl Med Mol Imaging

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“…Erdem and associates [ 108 ] conducted a study on FUO in 21 countries with different economic development. These authors based their investigation on the increased life expectancy with higher frequency of elderly people in high economic and social developed countries in comparison with those with limited resources [ 109 , 110 ].…”

Section: Fever Of Unknown Origin (Fuo) and Inflammation Of Unknown Or...mentioning

confidence: 99%

“…Particularly, age-associated diseases such as hypertension, diabetes and malignancies could be associated to FUO. On these grounds, Erdem and associates [ 108 ] selected 788 patients with FUO belonging to low-income, low middle-income, upper-middle income and high-income countries. Results show that FUO causes occur regardless of the economic status of the countries, and this factor does not influence the incidence of FUO worldwide.…”

Section: Fever Of Unknown Origin (Fuo) and Inflammation Of Unknown Or...mentioning

confidence: 99%

Microbial and Host Metabolites at the Backstage of Fever: Current Knowledge about the Co-Ordinate Action of Receptors and Molecules Underlying Pathophysiology and Clinical Implications

et al. 2023

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Fever represents an elevation of body temperature, that exerts a protective effect against pathogens. Innate immune cells and neurons are implicated in the regulation of body temperature. Pathogen-associated molecular patterns, i.e., lipopolysaccharides from Gram-negative bacteria and peptidoglycan and lipoteichoic acid from Gram-positive bacteria are exogenous pyrogens, that bind to Toll-like receptors on immune and non-immune cells. The subsequent release of pro-inflammatory cytokines [interleukin-1 (IL-1), IL-6 and Tumor necrosis factor-alpha] and their passage through the brain trigger the febrile response. In fact, neurons of the pre-optic area produce prostaglandin E2 (PGE2), that, in turn, bind to the PGE2 receptors; thus, generating fever. Apart from classical non-steroidal anti-inflammatory drugs, i.e., aspirin and acetaminophen, various botanicals are currently used as antipyretic agents and, therefore, their mechanisms of action will be elucidated.

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“…The infectious causes of FUO are complicated and varied, with significant differences among populations of different ages, regions, and immunologic status. Here, we selected a ddPCR detection panel for 12 common bacteria, 4 common fungi, and 8 antimicrobial-resistance genes according to the epidemiological survey of infectious agents responsible for pediatric FUO based on the global and Chinese populations [ [8] , [9] , [10] , [11] , [12] ]. Our study aimed to investigate the value of this ddPCR panel as a pathogen screening tool.…”

Section: Introductionmentioning

confidence: 99%

Droplet digital PCR aids in the diagnosis of children with fever of unknown origin ——A typical case report

Yang,

Hua,

Liu

et al. 2024

Heliyon

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Classical fever of unknown origin in 21 countries with different economic development: an international ID-IRI study

Cited by 8 publications

References 27 publications

[18F]FDG PET/CT for identifying the causes of fever of unknown origin (FUO)

[18F]FDG PET/CT for identifying the causes of fever of unknown origin (FUO)

Microbial and Host Metabolites at the Backstage of Fever: Current Knowledge about the Co-Ordinate Action of Receptors and Molecules Underlying Pathophysiology and Clinical Implications

Droplet digital PCR aids in the diagnosis of children with fever of unknown origin ——A typical case report

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