Classification and Management of Pancreatic Cysts

Byanova, Katerina L.; Gardner, Timothy B.

doi:10.1007/978-3-319-53091-8_5

Pancreatology 2017

DOI: 10.1007/978-3-319-53091-8_5

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Classification and Management of Pancreatic Cysts

Katerina L. Byanova

Timothy B. Gardner

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2021

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“…Pancreatic cancer (PC) is one of the leading causes of cancer-related death worldwide with an extremely poor prognosis 1,2 . Although pancreatic cysts are a heterogeneous group of diagnostic entities with a variable risk of progression to PC, they are to date the only PC precursors that can be reliably identified by cross-sectional imaging 3–5 . Despite several decades of study and the near universal acknowledgment of the rapid growth in the incidental diagnosis of pancreatic cysts, there still remain considerable gaps in the understanding of the epidemiology and natural history of these lesions, including the risk of progression to PC.…”

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confidence: 99%

Prevalence, Incidence, and Risk of Progression of Asymptomatic Pancreatic Cysts in Large Sample Real-world Data

et al. 2021

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Objectives: Using large-sample, real-world administrative claims data, we evaluated the prevalence of putatively asymptomatic pancreatic cysts, the historical growth in their incident diagnosis, and their risk of malignant progression.Methods: Data were sourced from IBM MarketScan administrative claims databases of more than 200 million patients. Period prevalence was assessed using 700,000 individuals without conditions that predispose to pancreatic cyst. The standardized cumulative incidence was compared with the cross-sectional abdominal imaging rate from 2010-2017. The risk of progression to pancreatic cancer for 14,279 newly diagnosed patients with a cyst was estimated using Kaplan-Meier analysis.Results: Standardized prevalence increased exponentially with age and was 1.84% (95% confidence interval, 1.80%-1.87%) for patients older than 45. Standardized incidence nearly doubled from 2010-2017 (6.3 to 11.4 per 10,000), whereas the imaging rate changed from only 8.0% to 9.4%. The cumulative risk of pancreatic cancer at 7 years was 3.0% (95% confidence interval, 2.4%-3.5%), increasing linearly (R 2 = 0.991) with an annual progression risk of 0.47%. Conclusions:Using large-sample data, we show a significant burden of asymptomatic pancreatic cysts, with an annual risk of progression to cancer of 0.47% for 7 years. Rapid growth in cyst diagnosis over the last decade far outpaced increases in the imaging rate.

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confidence: 99%

Prevalence, Incidence, and Risk of Progression of Asymptomatic Pancreatic Cysts in Large Sample Real-world Data

et al. 2021

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Classification and Management of Pancreatic Cysts

Cited by 1 publication

References 8 publications

Prevalence, Incidence, and Risk of Progression of Asymptomatic Pancreatic Cysts in Large Sample Real-world Data

Prevalence, Incidence, and Risk of Progression of Asymptomatic Pancreatic Cysts in Large Sample Real-world Data

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