Classification and prognosis of thyroid carcinoma

Thyroid cancer in Israel.

“…The fact that no change in incidence was noted between new and veteran residents in the country, nor between native and foreign born residents, strengthens such a hypothesis. The variation in the distribution of the various histological types with age, which is consistent with findings obtained in other studies (Woolner et al, 1961;Medina and Elliott, 1968) could also reflect a hormonal influence.…”

“…A variation in the relative frequency of histological tumour types with age. The higher incidence of thyroid cancer among females has been observed previously, both in population surveys (Mustacchi and Cutler, 1956;Tan, 1968) and in individual hospital data (Woolner et al, 1961). The higher susceptibility of women to this neoplasm may have particular epidemiological importance from a dual standpoint: (a) since most neoplastic tumours appear more frequently among males and (b) because practically all other thyroid disorders are also more frequent among women (Vander, Gaston and Dawber, 1968;Masi, Hartmann and Schulman, 1965;Alexander et al, 1966;Meyer, 1962).…”

Medullary Carcinoma of the Thyroid Gland

“…Amyloid was present in easily recognisable quantities in the stroma in all 21 cases described by Hazard and his colleagues, and they imply that the presence of amyloid is necessary for a diagnosis of medullary carcinoma to be made. Other pathologists have largely agreed with this view (Woolner et al, 1961;Williams et al, 1966), although Williams and his colleagues in their detailed studies of the pathological findings in medullary carcinoma, while excluding three cases from their review on the grounds that no amyloid could be identified microscopically, state that the absence of amyloid should not necessarily exclude the diagnosis of medullary carcinoma . This view has more recently been expressed with more conviction following the discovery that in some instances, although amyloid cannot be identified using the light microscope in what was thought to be a medullary carcinoma, electron microscopy reveals the presence of typical calcitonin secretory granules in the tumour cells (Normann et al, 1976).…”

Die Fernmetastasierung der Struma maligna

“…Häufigkeit und Lokalisation von Fernmetastasen bei Schilddrüsenkarzinomen wurden bereits von Heitz, Woolner, Silverberg und McCormack diskutiert [4,9,10,12], Die Art der Metastasierung bei der Struma maligna wird -mehr als bei allen anderen Organkarzinomen -von der Tumorhistologie bestimmt. Demnach besteht in der Literatur die weitverbrei tete Ansicht, daß die papillären SD-Karzinomc überwiegend lymphogen metastasieren, während follikuläre und anaplastische Karzinome, sowie mesenchymale Blastome vorwiegend hämatogene Metastasen setzen [1.…”