Classification of Angioid Streaks

McWilliam, R. J.

doi:10.1136/bjo.39.5.298

Cited by 10 publications

(2 citation statements)

References 6 publications

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“…He also commented on the loss of elasticity of the choriocapillaris and ciliary vascular network [3,9]. In later years, more histopathology reports and articles were released, supporting Böck's observations even further [5,[9][10][11][12][13][14].…”

Section: Pathophysiology Of the Condition And Histological Findingsmentioning

confidence: 89%

“…However, in 1917, Alfons Kofler was the first ophthalmologist to correctly propose that ASs are attributed to breaks in the Bruch membrane [3,5,7,8]. This postulation was further supported by histological studies in later years [5,[9][10][11][12][13][14]. Furthermore, in 2009, Charbel Issa and colleagues confirmed Kofler's hypothesis using in vivo imaging techniques [5,15].…”

Section: Historical Backgroundmentioning

confidence: 99%

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Angioid Streaks Remain a Challenge in Diagnosis, Management, and Treatment

Tsokolas,

Tossounis,

Tyradellis

et al. 2024

Vision

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Aim: Angioid streaks (ASs) are a rare retinal condition and compromise visual acuity when complicated with choroidal neovascularization (CNV). They represent crack-like dehiscences at the level of the Bruch’s membrane. This objective narrative review aims to provide an overview of pathophysiology, current treatment modalities, and future perspectives on this condition. Materials and Methods: A literature search was performed using “PubMed”, “Web of Science”, “Scopus”, “ScienceDirect”, “Google Scholar”, “medRxiv”, and “bioRxiv.” Results: ASs may be idiopathic, but they are also associated with systemic conditions, such as pseudoxanthoma elasticum, hereditary hemoglobinopathies, or Paget’s disease. Currently, the main treatment is the use of anti-vascular endothelial growth factors (anti-VEGF) to treat secondary CNV, which is the major complication observed in this condition. If CNV is detected and treated promptly, patients with ASs have a good chance of maintaining functional vision. Other treatment modalities have been tried but have shown limited benefit and, therefore, have not managed to be more widely accepted. Conclusion: In summary, although there is no definitive cure yet, the use of anti-VEGF treatment for secondary CNV has provided the opportunity to maintain functional vision in individuals with AS, provided that CNV is detected and treated early.

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