Classification of anxiety disorders: Changes, conundrums and consequences

Starčević, Vladan

doi:10.1177/0004867414557528

Cited by 2 publications

(3 citation statements)

References 5 publications

(6 reference statements)

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“…Our results give support to what is being proposed for the revision of the ICD11, that the group of disorders traditionally called “anxiety disorders” can be divided up into two distinct but related groups (Starcevic, 2014). We showed that decreasing the function of the 5HT system in patients in clinical remission leads to psychological and physiological exacerbation in response to stressors in the fear disorders (PTSD, panic and SAnD) though not in the anxiety disorders (GAD and OCD).…”

Section: Discussionsupporting

confidence: 86%

“…The conceptualization of the boundaries of anxiety disorders is an ongoing issue that is yet to be resolved (Starcevic, 2014). In DSM-5 , fear and anxiety disorders have been separated for the first time, with panic disorder and generalized anxiety disorder (GAD) in separate groups.…”

Section: Introductionmentioning

confidence: 99%

“…Also, posttraumatic stress disorder (PTSD) and obsessive–compulsive disorder (OCD) have been removed from the anxiety disorders group. Moreover, the ICD11 draft document refers to “anxiety and fear-related disorders”, which suggests different, but related conditions (Starcevic, 2014). In spite of a clear current demand for pathophysiological-based psychiatric nosology (Insel, 2014; Insel et al, 2010; Sanislow et al, 2010), none of the major re-conceptualizations have enough neurobiological support.…”

Section: Introductionmentioning

confidence: 99%

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Evidence for serotonin function as a neurochemical difference between fear and anxiety disorders in humans?

et al. 2015

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The relationships between serotonin and fear and anxiety disorders have been much studied yet many important questions remain, despite selective serotonin reuptake inhibitors having been the primary treatments for these disorders for some time. In order to explore this issue we performed a pooled analysis of six of our studies in remitted patients with a fear/anxiety disorder who were exposed to syndrome-specific aversive stimulation under acute tryptophan depletion. We based our analysis on the hypothesis that the inconsistencies observed in the studies could be predicted by Deakin and Graeff's theory about the dual role of serotonin in responses to threats, whereby serotonin is critical to prevent fear (panic) but not anxiety. In accordance with this view, our results give support to a dissociation of the disorders traditionally grouped under fear and anxiety-related disorders in terms of different roles of serotonin in modulation of responses to aversive stimulation. Implications for future studies and psychiatric nosology are discussed.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%